Marina Emborg, MD, PhD

Portrait of Marina Emborg, MD, PhD
Professor
Medical Physics
Address: 
Room 119 Primate
1220 Capitol Court
Madison, WI 53715
Telephone: 
(608) 262-9714
Focus Groups: 
Neuroscience/Neuropathology
Education: 
PhD, School of Medicine, Universidad de Buenos Aires
MD, School of Medicine, Universidad de Buenos Aires
Research Summary: 
Parkinson’s disease
Research Detail: 

Since her graduate studies Dr. Emborg's research focus has been in understanding and finding solutions for neurodegenerative disorders, with emphasis on Parkinson’s disease. Her body of work includes nonhuman primate models of neurological disorders, gene and cell-based therapies for Parkinson’s and the development of conceptual frameworks for ethical clinical translation of novel treatments. In 2004, she became faculty at the University of Wisconsin, Madison, where today she is the Director of the Preclinical Parkinson’s Research Program at the Wisconsin National Primate Research Center, and a Professor of Medical Physics. She is Editor of Neuroscience and Tissue Engineering Section for Cell Transplantation, past President of the American Society for Neural Therapy and Repair and the 2016 recipient of the Bernard Sanberg Memorial Award for Brain Repair (http://www.eurekalert.org/pub_releases/2016-05/uosf-uow043016.php).

Selected Publications: 
Vocalization development in common marmosets for neurodegenerative translational modeling. Jones CA, Duffy MK, Hoffman SA, Schultz-Darken NJ, Braun KM, Ciucci MR, Emborg ME. Neurol Res. 2018 Apr;40(4):303-311. doi: 10.1080/01616412.2018.1438226. Epub 2018 Feb 19. PMID: 29457539
In Vitro Modeling of Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S-Mediated Parkinson's Disease Pathology. Vermilyea SC, Emborg M. Stem Cells Dev. 2018 Feb 5. doi: 10.1089/scd.2017.0286. [Epubahead of print] PMID: 29402177
Metzger JM, Moore CF, Boetcher CA, Brunner KG, Fledderman RM. Matsoff HN, Resnikoff HA, Bondarenko V, Kamp TJ, Hacker TA, Barnhart TE, Lao PJ, Christian BT, Nickles RJ, Gallagher CL, Hoden JE, Emborg ME. In vivo imaging of Inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration. Nature Parkinson’s disease. 2018 (in press)
Nonhuman Primate Models of Neurodegenerative Disorders. Emborg ME. ILAR J. 2017 Dec 1;58(2):190-201. doi: 10.1093/ilar/ilx021. PMID: 28985333
Cross-species comparison of behavioral neurodevelopmental milestones in the common marmoset monkey and human child. Ausderau KK, Dammann C, McManus K, Schneider M, Emborg ME, Schultz-Darken N. Dev Psychobiol. 2017 Nov;59(7):807-821. doi: 10.1002/dev.21545. Epub 2017 Aug 1. PMID: 28763098
Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons from Adult Common Marmoset Fibroblasts. Vermilyea SC, Guthrie S, Meyer M, Smuga-Otto K, Braun K, Howden S, Thomson JA, Zhang SC,Emborg ME, Golos TG. Stem Cells Dev. 2017 Sep 1;26(17):1225-1235. doi: 10.1089/scd.2017.0069. Epub 2017 Jul 24. PMID: 28635509
The role of nonhuman primate models in the development of cell-based therapies for Parkinson's disease. Vermilyea SC, Emborg ME.J Neural Transm (Vienna). 2018 Mar;125(3):365-384. doi: 10.1007/s00702-017-1708-9. Epub 2017 Mar 22. Review. PMID: 28326445
Neurotoxin-Induced Catecholaminergic Loss in the Colonic Myenteric Plexus of Rhesus Monkeys. Shultz JM, Resnikoff H, Bondarenko V, Joers V, Mejia A, Simmons H, Emborg ME. J Alzheimers Dis Parkinsonism. 2016 Nov;6(6). pii: 279. doi: 10.4172/2161-0460.1000279. Epub 2016 Nov 3. PMID: 28090391
Real-Time Intraoperative MRI Intracerebral Delivery of Induced Pluripotent Stem Cell-Derived Neurons. Vermilyea SC, Lu J, Olsen M, Guthrie S, Tao Y, Fekete EM, Riedel MK, Brunner K, Boettcher C, Bondarenko V, Brodsky E, Block WF, Alexander A, Zhang SC, Emborg ME. Cell Transplant. 2017 Apr 13;26(4):613-624. doi: 10.3727/096368916X692979. Epub 2016 Sep14. PMID: 27633706
Overexpressing Corticotropin-Releasing Factor in the Primate Amygdala Increases Anxious Temperament and Alters Its Neural Circuit. Kalin NH, Fox AS, Kovner R, Riedel MK, Fekete EM, Roseboom PH, Tromp do PM, Grabow BP, Olsen ME, Brodsky EK, McFarlin DR, Alexander AL, Emborg ME, Block WF, Fudge JL, Oler JA. Biol Psychiatry. 2016 Sep 1;80(5):345-55. doi: 10.1016/j.biopsych.2016.01.010. Epub 2016 Jan 30. PMID: 27016385