Jenny Gumperz, PhD

Portrait of Jenny Gumperz, PhD
Associate Professor
Medical Microbiology and Immunology
4305 MSB
1550 Linden Drive
Madison, WI 53706
(608) 263-6902
Focus Groups: 
Cancer Biology
PhD, Stanford University, Stanford, CA
Research Summary: 
The Gumperz lab studies human innate T lymphocytes, with a particular focus on a subset called Natural Killer T (NKT) cells. NKT cells are able to affect the functions of many other types of immune cells, and in so doing they can markedly influence the outcome of immune responses. Because of this, and because they are activated by conserved antigens, NKT cells are of interest as a human lymphocyte population that could be harnessed clinically for immunotherapeutic strategies. What interests us about NKT cells is that they can become activated by self lipids, which means that they can perform functions even when there is no infectious challenge, and they can amplify immune responses without requiring the presence of a specific foreign antigen. One of the central questions my lab is addressing is to understand how this autoreactivity contributes to inflammatory responses and immune regulation. We are investigating these questions at the molecular and cellular levels, and also in the context of larger immunological processes such as graft-vs-host disease that occurs after transplantation of hematopoietic stem cells, and immune responses during Epstein-Barr virus infection.
Research Detail: 

Please see Gumperz Lab

Selected Publications: 
Modeling Human Antitumor Responses In Vivo Using Umbilical Cord Blood-Engrafted Mice. Zumwalde NA, Gumperz JE. Front Immunol. 2018 Jan 26;9:54. doi: 10.3389/fimmu.2018.00054. eCollection 2018. Review. PMID: 29434589
Adoptively transferred Vγ9Vδ2 T cells show potent antitumor effects in a preclinical B cell lymphomagenesis model. Zumwalde NA, Sharma A, Xu X, Ma S, Schneider CL, Romero-Masters JC, Hudson AW, Gendron-Fitzpatrick A, Kenney SC, Gumperz JE. JCI Insight. 2017 Jul 6;2(13). pii: 93179. doi: 10.1172/jci.insight.93179. [Epub ahead of print] PMID: 28679955
Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs. Xu X, Pocock GM, Sharma A, Peery SL, Fites JS, Felley L, Zarnowski R, Stewart D, Berthier E, Klein BS, Sherer NM, Gumperz JE. Cell Rep. 2016 Sep 20;16(12):3273-3285. doi: 10.1016/j.celrep.2016.08.061. PMID: 27653689
Human Invariant NKT Cells Induce IL-1β Secretion by Peripheral Blood Monocytes via a P2X7-Independent Pathway. Felley LE, Sharma A, Theisen E, Romero-Masters JC, Sauer JD, Gumperz JE. J Immunol. 2016 Sep 15;197(6):2455-64. doi: 10.4049/jimmunol.1600790. Epub 2016 Aug 17. PMID: 27534556
Are human iNKT cells keeping tabs on lipidome perturbations triggered by oxidative stress in the blood? Felley L, Gumperz JE. Immunogenetics. 2016 Aug;68(8):611-22. doi: 10.1007/s00251-016-0936-8. Epub 2016 Jul 8. Review. PMID: 27393663
PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model. Ma SD, Xu X, Jones R, Delecluse HJ, Zumwalde NA, Sharma A, Gumperz JE, Kenney SC. PLoS Pathog. 2016 May 17;12(5):e1005642. doi: 10.1371/journal.ppat.1005642. eCollection 2016 May. PMID: 27186886
Analysis of Immune Cells fromHuman Mammary Ductal Epithelial Organoids Reveals Vδ2+ T Cells That Efficiently Target Breast Carcinoma Cells in the Presence of Bisphosphonate. Zumwalde NA, Haag JD, Sharma D, Mirrielees JA, Wilke LG, Gould MN, Gumperz JE. Cancer Prev Res (Phila). 2016 Apr;9(4):305-16. doi: 10.1158/1940-6207.CAPR-15-0370-T. Epub 2016 Jan 25. PMID: 26811335
LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis. Ma SD, Xu X, Plowshay J, Ranheim EA, Burlingham WJ, Jensen JL, Asimakopoulos F, Tang W, Gulley ML, Cesarman E, Gumperz JE, Kenney SC. J Clin Invest. 2015 Jan;125(1):304-15. doi: 10.1172/JCI76357. Epub 2014 Dec 8. PMID: 25485679
Transcriptional regulation of the human TNFSF11 gene in T cells via a cell type-selective set of distal enhancers. Bishop KA, Wang X, Coy HM, Meyer MB, Gumperz JE, Pike JW. J Cell Biochem. 2015 Feb;116(2):320-30. doi: 10.1002/jcb.24974. PMID: 25211367
Expression of CD1c enhances human invariant NKT cell activation by α-GalCer. Fox LM, Miksanek J, May NA, Scharf L, Lockridge JL, Veerapen N, Besra GS, Adams EJ, Hudson AW, Gumperz JE. Cancer Immun. 2013 May 10;13:9. Print 2013. PMID: 23885215