Dr. Gern leads several NIH-funded studies to define the role of viral infections in the initiation and disease activity of asthma, and to identify interactions between host and viral factors that determine the severity of respiratory illnesses. He leads the Urban Environment and Childhood Asthma (URECA) study for the Inner City Asthma Consortium, and the Wisconsin Infant Study Cohort in Marshfield. The goals of the birth cohort studies are to identify lifestyle and environmental factors (including viral infections) unique to the urban and farming environments that influence early immune development which modify the risks for allergic diseases and asthma. Dr. Gern also leads translational research projects to identify virus-induced inflammatory mechanisms involving airway epithelial cells, and experimental inoculation studies of volunteers with asthma using a safety-tested strain of rhinovirus. Finally, The Gern lab group is conducting experiments to define the basic biology of a newly discovered species of rhinovirus (HRV-C) that provokes wheezing episodes and exacerbations of asthma.
James E. Gern, MD
600 Highland Avenue
Madison, WI 53792
MD, University of Southern Florida, Tampa
Pediatrics: SUNY-Syracuse, Tufts University
Allergy/Immunology, John Hopkins University
To define the role of viral infections in the initiation and disease activity of asthma, and to identify interactions between host and viral factors that determine the severity of respiratory illnesses
Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, Printz MC, Lee WM, Shult PA, Reisdorf E, Carlson-Dakes KT, Salazar LP, DaSilva DF, Tisler CJ, Gern JE, Lemanske RF Jr. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008 Oct 1;178(7):667-72. Epub 2008 Jun 19.
Jakiela B, Brockman-Schneider R, Amineva S, Lee WM, Gern JE. Basal cells of differentiated bronchial epithelium are more susceptible to rhinovirus infection, Am J Respir Cell Mol Biol. 38:517-23, 2008.
Gern JE, Visness CM, Gergen PJ, Wood RA, Bloomberg GR, O'Connor GT, Kattan M, Sampson HA, Witter FR, Sandel MT, Shreffler WG, Wright RJ, Arbes SJ Jr, Busse WW. The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population. BMC Pulm Med. 2009 May 8;9:17.
Gold DR, Bloomberg GR, Cruikshank WW, Visness CM, Schwarz J, Kattan M, O’Connor GT, Wood RA, Burger MS, Wright RJ, Witter F, Lee-Paritz A, Sperling R, Sadovsky Y, Togias A, and Gern JE. Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses. J Allergy Clin Immunol. 2009;124(5):1078-87.
Bochkov YA, Hanson KM, Keles S, Brockman-Schneider RA, Jarjour NN, and Gern JE. Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma. Molecular Immunol 2010 Jan;3(1):69-80.
Olenec JP, Kim WK, Lee WM, Vang F, Pappas TE, Salazar LEP, Evans MD, Bork J, Roberg K, Lemanske RF Jr, and Gern JE. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol 2010;125:1001-6.
Denlinger LC, Shi L, Guadarrama A, Schell K, Green D, Morrin A, Hogan K, Sorkness RL, Busse WW, Gern JE. Attenuated P2X7 pore function as a risk factor for virus-induced loss of asthma control. Am J Respir Crit Care Med. 2009 Feb 15;179(4):265-70. Epub 2008 Nov 21.
Wood RA, Bloomberg GR, Kattan M, Conroy K, Sandel MT, Dresen A, Gergen PJ, Gold DR, Schwarz JC, Visness CM, and Gern JE. Relationships among Environmental Exposures, Cord Blood Cytokine Responses, Allergy, and Wheeze at One Year of Age in an Inner-City Birth Cohort (URECA). J Allergy Clin Immunol 2011;127:913-919.
Bochkov Y, Palmenberg AC, Lee WM, Rathe JA, Amineva SP, Sun X, Pasic TR, Jarjour NN, Liggett SB, and Gern JE. Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nat Medicine 2011;17:627-32.
Kloepfer KM, Olenec JP, Lee WM, Liu G, Vrtis RF, Roberg KA, Evans MD, Gangnon RE, Lemanske RF Jr, and Gern JE. Increased H1N1 infection rate in children with asthma. Am J Respir Crit Care Med 2012;185:1275-1279.
Lee WM, Lemanske RF Jr, Evans MD, Vang F, Pappas T, Gangnon R, Jackson DJ, and Gern JE. Human rhinovirus species and season of infection determine illness severity. Am J Respir Crit Care Med 2012;186:886-91. doi: 10.1164/rccm.201202-0330OC.
Ashraf S, Brockman-Schneider R, Bochkov YA, Pasic TR, Gern JE. Biological characteristics and propagation of human rhinovirus-C in differentiated sinus epithelial cells. Virology 2012, http://dx.doi.org/10.1016/j.virol.2012.11.002
Calışkan M, Bochkov YA, Kreiner-Møller E, Bønnelykke K, Stein MM, Du G, Bisgaard H, Jackson DJ, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C. Rhinovirus Wheezing Illness and Genetic Risk of Childhood-Onset Asthma. N Engl J Med. 2013;368(15):1398-407.
Nakagome K, Bochkov YA, Ashraf S, Brockman-Schneider RA, Evans MD, Pasic TR and Gern JE. Effects of rhinovirus species on viral replication and cytokine production. J Allergy Clin Immunol 2014 (In press).
Kloepfer KM, Lee WM, Pappas TE, Kang T, Vrtis RF, Evans MD, Gangnon RE, Bochkov YA, Lemanske RF Jr. and Gern JE. Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and exacerbations of asthma. J Allergy Clin Immunol 2014 May;133(5):1301-1307
Lynch SV, Wood RA, Boushey H, Bacharier LB, Bloomberg GR, Kattan M, O'Connor GT, Sandel MT, Calatroni A, Matsui E, Johnson CC, Lynn H, Visness CM, Jaffee KF, Gergen PJ, Gold DR, Wright RJ, Fujimura K, Rauch M, Busse WW, Gern JE. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol 2014 (In press).