James E. Gern, MD

Portrait of James E. Gern, MD
Professor
Pediatrics
Address: 
K4/918 CSC
600 Highland Avenue
Madison, WI 53792
Telephone: 
(608) 263-6201
Focus Groups: 
Immunology/Immunopathology
Education: 
MD, University of Southern Florida, Tampa
Pediatrics: SUNY-Syracuse, Tufts University
Allergy/Immunology, John Hopkins University
Research Summary: 
To define the role of viral infections in the initiation and disease activity of asthma, and to identify interactions between host and viral factors that determine the severity of respiratory illnesses
Research Detail: 

Dr. Gern leads several NIH-funded studies to define the role of viral infections in the initiation and disease activity of asthma, and to identify interactions between host, viral and enviornmental factors that determine the severity of respiratory illnesses. He leads the Urban Environment and Childhood Asthma (URECA) study for the Inner-City Asthma Consortium, the Wisconsin Infant Study Cohort in Marshfield, and a consortium of asthma birth cohorts as part of the national ECHO study. The goals of the birth cohort studies are to identify lifestyle and environmental factors (including viral infections) unique to the urban and farming environments that influence early immune development which modify the risks for allergic diseases and asthma. Dr. Gern also leads translational research projects to identify virus-induced inflammatory mechanisms involving airway epithelial cells. Finally, The Gern lab group is conducting experiments to define the basic biology of a newly discovered species of rhinovirus (RV-C) that provokes wheezing episodes and exacerbations of asthma.

Selected Publications: 
Glycation of whey protein with dextrans of different molar mass: Effect on immunoglobulin E-binding capacity with blood sera obtained from patients with cow milk protein allergy. Xu L, Gong Y, Gern JE, Ikeda S, Lucey JA. J Dairy Sci. 2018 May 16. pii: S0022-0302(18)30500-9. doi: 10.3168/jds.2017-14338. [Epub ahead of print] PMID: 29778476
Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes. Thompson EE, Nicodemus-Johnson J, Kim KW, Gern JE, Jackson DJ, Lemanske RF, Ober C. Clin Epigenetics. 2018 May 9;10:62. doi: 10.1186/s13148-018-0491-2. eCollection 2018. PMID: 29760811
A new model of wheezing severity in young children using the validated ISAAC wheezing module: A latent variable approach with validation in independent cohorts. Brunwasser SM, Gebretsadik T, Gold DR, Turi KN, Stone CA Jr., Datta S, Gern JE, Hartert TV. PLoS One. 2018 Apr 17;13(4):e0194739. doi: 10.1371/journal.pone.0194739. eCollection 2018. PMID: 29664908
Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma. Altman MC, Whalen E, Togias A, O'Connor GT, Bacharier LB, Bloomberg GR, Kattan M, Wood RA, Presnell S, LeBeau P, Jaffee K, Visness CM, Busse WW, Gern JE. J Allergy Clin Immunol. 2018 Mar 5. pii: S0091-6749(18)30307-5. doi: 10.1016/j.jaci.2018.02.019. [Epub ahead of print] PMID: 29518416
Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy. Kattan M, Bacharier LB, O'Connor GT, Cohen R, Sorkness RL, Morgan W, Gergen PJ, Jaffee KF, Visness CM, Wood RA, Bloomberg GR, Doyle S, Burton R, Gern JE. J Allergy ClinImmunol Pract. 2018 Feb 13. pii: S2213-2198(18)30015-1. doi: 10.1016/j.jaip.2017.12.028. [Epub ahead of print] PMID: 29449165
Development of Asthma in Inner-City Children: Possible Roles of MAIT Cells and Variation in the Home Environment. Chandra S, Wingender G, Greenbaum JA, Khurana A, Gholami AM, Ganesan AP, Rosenbach M, Jaffee K, Gern JE, Wood R, O'Connor G, Sandel M, Kattan M, Bacharier L, Togias A, Horner AA, Kronenberg M. J Immunol. 2018 Mar 15;200(6):1995-2003. doi: 10.4049/jimmunol.1701525. Epub 2018 Feb 5. PMID: 29431692
Lethal Respiratory Disease Associated with Human Rhinovirus C in Wild Chimpanzees, Uganda, 2013. Scully EJ, Basnet S, Wrangham RW, Muller MN, Otali E, Hyeroba D, Grindle KA, Pappas TE, Thompson ME, Machanda Z, Watters KE, Palmenberg AC, Gern JE, Goldberg TL. Emerg Infect Dis. 2018 Feb;24(2):267-274. doi: 10.3201/eid2402.170778. PMID: 29350142
Viral Infections and Associated Factors That Promote Acute Exacerbations of Asthma. Kim CK, Callaway Z, Gern JE. Allergy Asthma Immunol Res. 2018 Jan;10(1):12-17. doi: 10.4168/aair.2018.10.1.12. Review. PMID: 29178673
Microbial volatile communication in human organotypic lung models. Barkal LJ, Procknow CL, Álvarez-García YR, Niu M, Jiménez-Torres JA, Brockman-Schneider RA, Gern JE, Denlinger LC, Theberge AB, Keller NP, Berthier E, Beebe DJ. Nat Commun. 2017 Nov 24;8(1):1770. doi: 10.1038/s41467-017-01985-4. PMID: 29176665
Cadherin-related Family Member 3 Genetics and Rhinovirus C Respiratory Illnesses. Bønnelykke K, Coleman AT, Evans MD, Thorsen J, Waage J, Vissing NH, Carlsson CJ, Stokholm J, Chawes BL, Jessen LE, Fischer TK, Bochkov YA, Ober C, Lemanske RF Jr., Jackson DJ, Gern JE, Bisgaard H. Am J Respir Crit Care Med. 2018 Mar 1;197(5):589-594. doi: 10.1164/rccm.201705-1021OC. PMID: 29121479