Wade Bushman, MD, PhD

Portrait of Wade Bushman, MD, PhD
K6/561 CSC
600 Highland Avenue
Madison, WI 53792
(608) 262-5440
Focus Groups: 
Cancer Biology
Signal Transduction
MD, University of Chicago, Chicago, IL
PhD, Brown University, Providence, RI
Research Summary: 
Hedgehog signaling in prostate development and prostate cancer; role of inflammatory signaling in regenerative-repair, hyperplasia and neoplasia; Role of prostate inflammation in producing prostate obstruction and changes in bladder function
Research Detail: 

Previous studies in our laboratory have provided evidence for paracrine Hh signaling in normal prostate development and human prostate cancer and shown that Hh signaling can accelerate xenograft tumor growth by a paracrine mechanism. We are now characterizing the target genes of paracrine activation and examining how the stromal phenotype determines the cassette of target genes expressed and the overall effect on epithelial proliferation and tumor growth. Complementary studies are examining the role of autocrine signaling in normal development and cancer.

Selected Publications: 
Dual regulation of decorin by androgen and Hedgehog signaling during prostate morphogenesis. Montano M, Dinnon KH, Jacobs L, Xiang W, Iozzo RV, Bushman W. Dev Dyn. 2018 May;247(5):679-685. doi: 10.1002/dvdy.24619. Epub2018 Feb 19. PMID: 29368411
Urosymphyseal Fistulas Resulting From Endoscopic Treatment of Radiation-induced Posterior Urethral Strictures. Shapiro DD, Goodspeed DC, Bushman W. Urology. 2018 Apr;114:207-211. doi: 10.1016/j.urology.2017.12.020. Epub 2018 Jan 3. PMID: 29305945
Utility of routine urinalysis and urine culture testing in an ambulatory urology clinic: a quality improvement initiative in a Veterans healthcare facility. Richards KA, Cesario S, Lim AH, Best SL, Deeren SM, Bushman W, Safdar N. Can J Urol. 2017 Feb;24(1):8627-8633. PMID: 28263127
Assessing the Variability in Insurance Coverage Transparency for Male Sexual Health Conditions in the United States. Le B, McAchran S, Paolone D, Gralnek D, Williams D 4th, Bushman W. Urology. 2017 Apr;102:126-129. doi: 10.1016/j.urology.2016.12.031. Epub 2016 Dec 23. PMID: 28024968
Morphoregulatory pathways in prostate ductal development. Montano M, Bushman W. Dev Dyn. 2017 Feb;246(2):89-99. doi: 10.1002/dvdy.24478. Review. PMID: 27884054
Hedgehog Signaling inProstate Development, Regeneration and Cancer. Bushman W. J Dev Biol. 2016 Oct 19;4(4). pii: E30. doi: 10.3390/jdb4040030. Review. PMID: 29615593
In-Depth Characterization and Validation of Human Urine Metabolomes Reveal Novel Metabolic Signatures of Lower Urinary Tract Symptoms. Hao L, Greer T, Page D, Shi Y, Vezina CM, Macoska JA, Marker PC, Bjorling DE, Bushman W, Ricke WA, Li L. Sci Rep. 2016 Aug 9;6:30869. doi: 10.1038/srep30869. PMID: 27502322
The role of prostate inflammation and fibrosis in lower urinary tract symptoms. Bushman WA, Jerde TJ. Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F817-F821. doi: 10.1152/ajprenal.00602.2015. Epub 2016 Jul 20. Review. PMID: 27440781
Retrograde double-labeling demonstrates convergent afferent innervation of the prostate and bladder. Lee S, Yang G, Xiang W, Bushman W. Prostate. 2016 Jun;76(8):767-75. doi: 10.1002/pros.23170. Epub 2016 Mar 4. PMID: 26939943
Custom 4-Plex DiLeu Isobaric Labels Enable Relative Quantification of Urinary Proteins in Men with Lower Urinary Tract Symptoms (LUTS). Greer T, Hao L, Nechyporenko A, Lee S, Vezina CM, Ricke WA, Marker PC, Bjorling DE, Bushman W, Li L. PLoS One. 2015 Aug 12;10(8):e0135415. doi: 10.1371/journal.pone.0135415. eCollection 2015. PMID: 26267142