Michelle E. Kimple, PhD

Portrait of Michelle E. Kimple, PhD
Assistant Professor
Medicine
Address: 
C4149C VAMC
2500 Overlook Terrace
Madison, WI 53792
Telephone: 
(608) 256-1901 x12861
Focus Groups: 
Signal Transduction
Education: 
PhD, Biochemistry & Biophysics, University of North Carolina-Chapel Hill
Postdoctoral,Pharmacology & Cancer Biology, Duke University
Research Summary: 
Guanine Nucleotide Binding Proteins, pancreatic beta-cell biology, insulin secretion, diabetes pathophysiology
Research Detail: 

Dr. Kimple leads a multi-level research team whose focus is on understanding how the beta-cells of the pancreas respond to nutrient and hormonal stimulation to affect biological changes. Her group is especially interested in elucidating how dysfunctional G protein-coupled receptor signaling pathways contribute to the pathogenesis of type 1 and type 2 diabetes and in translating these insights into new and improved diabetes therapeutics. Dr. Kimple's research has been funded almost continuously from her PhD onwards by the National Institutes of Health and the Juvenile Diabetes Research Foundation, among other agencies. Her work has been featured in several university press releases and patent applications. Dr. Kimple has been the recipient of several awards, including a Preparing Future Faculty Fellowship from Duke University, where she learned the skills necessary to be a successful mentor and teacher while maintaining a top-tier research laboratory.

Selected Publications: 
Targeting dysfunctional beta-cell signaling for the potential treatment of type 1 diabetes mellitus. Fenske RJ, Kimple ME. Exp Biol Med (Maywood). 2018 Mar;243(6):586-591. doi: 10.1177/1535370218761662. Epub 2018 Mar 4. PMID: 29504478
Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms. Yu D, Yang SE, Miller BR, Wisinski JA, Sherman DS, Brinkman JA, Tomasiewicz JL, Cummings NE, Kimple ME, Cryns VL, Lamming DW. FASEB J. 2018 Jan 30:fj201701211R. doi: 10.1096/fj.201701211R. [Epub ahead of print] PMID: 29401631
Restoration of metabolic health by decreased consumption of branched-chain amino acids. Cummings NE, Williams EM, Kasza I, Konon EN, Schaid MD, Schmidt BA, PoudelC, Sherman DS, Yu D, Arriola Apelo SI, Cottrell SE, Geiger G, Barnes ME, Wisinski JA, Fenske RJ, Matkowskyj KA, Kimple ME, Alexander CM, Merrins MJ, Lamming DW. J Physiol. 2018 Feb 15;596(4):623-645. doi: 10.1113/JP275075. Epub 2017 Dec 27. PMID: 29266268
EPAC-RAP1 Axis-Mediated Switch in the Response of Primary and Metastatic Melanoma to Cyclic AMP. Rodríguez CI, Castro-Pérez E, Prabhakar K, Block L, Longley BJ, Wisinski JA, Kimple ME, Setaluri V. Mol Cancer Res. 2017 Dec;15(12):1792-1802. doi: 10.1158/1541-7786.MCR-17-0067. Epub 2017 Aug 29. PMID: 28851815
The EP3 Receptor/Gz Signaling Axis as a Therapeutic Target for Diabetes and Cardiovascular Disease. Schaid MD, Wisinski JA, Kimple ME. AAPS J. 2017 Sep;19(5):1276-1283. doi: 10.1208/s12248-017-0097-1. Epub 2017 Jun 5. Review. PMID: 28584908
Opposing effects of prostaglandin E2 receptors EP3 and EP4 on mouse and human β-cell survival and proliferation. Carboneau BA, Allan JA, Townsend SE, Kimple ME, Breyer RM, Gannon M. Mol Metab. 2017 Apr 5;6(6):548-559.doi: 10.1016/j.molmet.2017.04.002. eCollection 2017 Jun. PMID: 28580285
Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes. Hernandez R, Graves SA, Gregg T, VanDeusen HR, Fenske RJ, Wienkes HN, England CG, Valdovinos HF, Jeffery JJ, Barnhart TE, Severin GW, Nickles RJ, Kimple ME, Merrins MJ, Cai W. Diabetes. 2017 Aug;66(8):2163-2174. doi: 10.2337/db16-1285. Epub 2017 May 17. PMID: 28515126
Dietary polyunsaturated fatty acids and their metabolites: Implications for diabetes pathophysiology, prevention, and treatment. Neuman JC, Fenske RJ, Kimple ME. Nutr Healthy Aging. 2017 Mar 31;4(2):127-140. doi: 10.3233/NHA-160004. Review. No abstract available. PMID: 28447067
The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice. Fenske RJ, Cadena MT, Harenda QE, Wienkes HN, Carbajal K, Schaid MD, Laundre E, Brill AL, Truchan NA, Brar H, Wisinski J, Cai J, Graham TE, Engin F, Kimple ME. Endocrinology. 2017 Jun 1;158(6):1645-1658. doi: 10.1210/en.2016-1700. PMID: 28419211
Enriching Islet Phospholipids With Eicosapentaenoic Acid Reduces Prostaglandin E2 Signaling and Enhances Diabetic β-Cell Function. Neuman JC, Schaid MD, Brill AL, Fenske RJ, Kibbe CR, Fontaine DA, Sdao SM, Brar HK, Connors KM, Wienkes HN, Eliceiri KW, Merrins MJ, Davis DB, Kimple ME. Diabetes. 2017 Jun;66(6):1572-1585. doi: 10.2337/db16-1362. Epub 2017 Feb 13. PMID: 28193789