Karl W. Broman, PhD

Portrait of Karl W. Broman, PhD
Biostatistics and Medical Informatics
6763 MSC
1300 University Ave
Madison, WI 53706
(608) 262-4633
Focus Groups: 
Signal Transduction
PhD, Statistics, University of California, Berkeley
Research Summary: 
Statistics and statistical genetics
Research Detail: 

I am interested in statistical problems in genetics, genomics, and molecular biology. I am particularly interested in the development of improved methods for detecting and identifying genes contributing to variation in complex traits in humans and experimental organisms.

Selected Publications: 
Genetic Drivers of Pancreatic Islet Function. Keller MP, Gatti DM, Schueler KL, Rabaglia ME, Stapleton DS, Simecek P, Vincent M, Allen S, Broman AT, Bacher R, Kendziorski C, Broman KW, Yandell BS, Churchill GA, Attie AD.Genetics. 2018 May;209(1):335-356. doi: 10.1534/genetics.118.300864. Epub 2018 Mar 22. PMID: 29567659
Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats
Keele GR, Prokop JW, He H, Holl K, Littrell J, Deal A,Francic S, Cui L, Gatti DM, Broman KW, Tschannen M, Tsaih SW, Zagloul M, Kim Y, Baur B, Fox J, Robinson M, Levy S, Flister MJ, Mott R, Valdar W, Solberg Woods LC. Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28. PMID: 29193816
The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets. Keller MP, Paul PK, Rabaglia ME, Stapleton DS, Schueler KL, Broman AT, Ye SI, Leng N, Brandon CJ, Neto EC, Plaisier CL, Simonett SP, Kebede MA, Sheynkman GM, Klein MA, Baliga NS, Smith LM, Broman KW, Yandell BS, Kendziorski C, Attie AD. PLoS Genet. 2016 Dec 9;12(12):e1006466. doi: 10.1371/journal.pgen.1006466. eCollection 2016 Dec. PMID: 27935966
Recombination rate variation in mice from an isolated island. Wang RJ, Gray MM, Parmenter MD, Broman KW, Payseur BA. Mol Ecol. 2017 Jan;26(2):457-470. doi: 10.1111/mec.13932. Epub 2016 Dec 21. PMID: 27864900
Genetics of Skeletal Evolution in Unusually Large Mice from GoughIsland. Parmenter MD, Gray MM, Hogan CA, Ford IN, Broman KW, Vinyard CJ, Payseur BA. Genetics. 2016 Dec;204(4):1559-1572. Epub 2016 Sep 30. PMID: 27694627
A Spontaneous Missense Mutation in Branched Chain Keto Acid Dehydrogenase Kinase in the Rat Affects Both the Central and Peripheral Nervous Systems. Zigler JS Jr, Hodgkinson CA, Wright M, Klise A, Sundin O, Broman KW, Hejtmancik F, Huang H, Patek B, Sergeev Y, Hose S, Brayton C, Xaiodong J, Vasquez D, Maragakis N, Mori S, Goldman D, Hoke A, Sinha D. PLoSOne. 2016 Jul 29;11(7):e0160447. doi: 10.1371/journal.pone.0160447. eCollection 2016. PMID: 27472223
Mapping genetic determinants of host susceptibility to Pseudomonas aeruginosa lung infection in mice. De Simone M, Spagnuolo L, Lorè NI, Cigana C, De FinoI, Broman KW, Iraqi FA, Bragonzi A
The Dissection of Expression Quantitative Trait Locus Hotspots. Tian J, Keller MP, Broman AT, Kendziorski C, Yandell BS, Attie AD, Broman KW. Genetics. 2016 Apr;202(4):1563-74. doi: 10.1534/genetics.115.183624. Epub 2016Feb 2. PMID: 26837753. BMC Genomics. 2016 May 11;17:351. doi: 10.1186/s12864-016-2676-4. PMID: 27169516
Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice. Gruhn JR, Al-Asmar N, Fasnacht R, Maylor-Hagen H, Peinado V, Rubio C, Broman KW, Hunt PA, Hassold T. Am J Hum Genet. 2016 Jan 7;98(1):102-15. doi: 10.1016/j.ajhg.2015.11.019. Epub 2015 Dec 31. PMID: 26749305