Dr. Gern leads several NIH-funded studies to define the role of viral infections in the initiation and disease activity of asthma, and to identify interactions between host and viral factors that determine the severity of respiratory illnesses. He leads the Urban Environment and Childhood Asthma (URECA) study for the Inner City Asthma Consortium, and the Wisconsin Infant Study Cohort in Marshfield. The goals of the birth cohort studies are to identify lifestyle and environmental factors (including viral infections) unique to the urban and farming environments that influence early immune development which modify the risks for allergic diseases and asthma. Dr. Gern also leads translational research projects to identify virus-induced inflammatory mechanisms involving airway epithelial cells, and experimental inoculation studies of volunteers with asthma using a safety-tested strain of rhinovirus. Finally, The Gern lab group is conducting experiments to define the basic biology of a newly discovered species of rhinovirus (HRV-C) that provokes wheezing episodes and exacerbations of asthma.
James E. Gern, MD
600 Highland Avenue
Madison, WI 53792
MD, University of Southern Florida, Tampa
Pediatrics: SUNY-Syracuse, Tufts University
Allergy/Immunology, John Hopkins University
To define the role of viral infections in the initiation and disease activity of asthma, and to identify interactions between host and viral factors that determine the severity of respiratory illnesses
Lee WM, Lemanske RF Jr, Evans MD, Vang F, Pappas T, Gangnon R, Jackson DJ, and Gern JE. Human rhinovirus species and season of infection determine illness severity. Am J Respir Crit Care Med 2012;186:886-91. doi: 10.1164/rccm.201202-0330OC.
Kloepfer KM, Olenec JP, Lee WM, Liu G, Vrtis RF, Roberg KA, Evans MD, Gangnon RE, Lemanske RF Jr, and Gern JE. Increased H1N1 infection rate in children with asthma. Am J Respir Crit Care Med 2012;185:1275-1279.
Ashraf S, Brockman-Schneider R, Bochkov YA, Pasic TR, Gern JE. Biological characteristics and propagation of human rhinovirus-C in differentiated sinus epithelial cells. Virology 2012, http://dx.doi.org/10.1016/j.virol.2012.11.002
Wood RA, Bloomberg GR, Kattan M, Conroy K, Sandel MT, Dresen A, Gergen PJ, Gold DR, Schwarz JC, Visness CM, and Gern JE. Relationships among Environmental Exposures, Cord Blood Cytokine Responses, Allergy, and Wheeze at One Year of Age in an Inner-City Birth Cohort (URECA). J Allergy Clin Immunol 2011;127:913-919.
Bochkov Y, Palmenberg AC, Lee WM, Rathe JA, Amineva SP, Sun X, Pasic TR, Jarjour NN, Liggett SB, and Gern JE. Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nat Medicine 2011;17:627-32.
Olenec JP, Kim WK, Lee WM, Vang F, Pappas TE, Salazar LEP, Evans MD, Bork J, Roberg K, Lemanske RF Jr, and Gern JE. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol 2010;125:1001-6.
Rathe JA, Liu X, Tallon LJ, Gern JE, Liggett SB. Full-genome sequence and analysis of a novel human rhinovirus strain within a divergent HRV-A clade. Arch Virol 2010 2010;155(1):83-7.
Bochkov YA, Hanson KM, Keles S, Brockman-Schneider RA, Jarjour NN, and Gern JE. Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma. Molecular Immunol 2010 Jan;3(1):69-80.
Singh AM, Evans MD, Gangnon R, Roberg KA, Tisler C, DaSilva D, Pappas T, Salazar L, Anderson EL, Gern JE, Lemanske RF Jr and Seroogy CM. Expression patterns of atopic eczema and respiratory illnesses in a high-risk birth cohort. J Allergy Clin Immunol 2010 125:491-3.