Immunology/Immunopathology Trainers

The graduate faculty and a brief statement of their research interests are listed below. Many of these individual research programs are funded by awards from a variety of funding resources. Inquiries regarding space in a laboratory and availability of research support should be directed to the individual faculty member.

Portrait of David R. Andes, MD
Research Summary: Antimicrobial resistance development and therapy, Fungal pathogenesis, Candida biofilm pathogenesis and resistance, preclinical anti-infective drug development
Portrait of Lisa M. Arendt, DVM, PhD
Comparative Biosciences
Research Summary: Breast cancer, tumor/stromal interactions, cancer stem cells, mammary stem cells, Human-in-Mouse Model, inflammation and tumor microenvironment, adipose stem cells
Portrait of Fotis Asimakopoulos, MB, BChir, PhD
Research Summary: Myeloma research and phase I experimental therapeutics
Portrait of William Burlingham, PhD
Research Summary: Acquired immunologic tolerance; graft acceptance through the study of transplant recipients who have survived even though they have stopped taking immunosuppressive drugs; Th17 and Treg development
Portrait of Christian Capitini, MD
Research Summary: Using mouse models of allogeneic blood and marrow transplantation (alloBMT) to optimize therapies that prevent graft-versus-host-disease (GVHD) and maximize graft-versus-tumor (GVT) effects
Portrait of Cameron R. Currie, PhD
Research Summary: Evolution of host-microbe interactions, including both pathogenic and beneficial microbes. We are particularly interested in: i) the evolution of virulence, ii) determining the factors that shape host-microbe specificity, iii) exploring factors limiting and/or facilitating broad host jumps, iv) and host-microbe coevolutionary dynamics. Our main model system is the fungus-growing ant–microbe symbiosis.
Portrait of Loren Clark Denlinger, MD, PhD
Research Summary: Host-pathogen interactions; the role of macrophages in immunity to intracellular pathogens; innate immune responses like cytokine production & microbial killing amplified by extracellular nucleotide receptor known as P2X7 (significant functional diversity for this receptor exists between cell types & human subjects); role of P2X7 as candidate gene modulating the human innate immune responses of macrophages & airway epithelial cells to Chlamydia pneumoniae, contribution of responses of asthma
Portrait of Arjang Djamali, MD
Research Summary: The cellular and molecular mechanisms of fibrogenesis in native and transplant kidney disease
Portrait of Feyza Engin, PhD
Biomolecular Chemistry
Research Summary: Type 1 diabetes (T1D) results from the destruction of the insulin-secreting b-cells by an immune mediated process. The increasing incidence of type 1 diabetes around the word, especially among children, has been of great concern.
Portrait of David Evans, PhD
Pathology and Laboratory Medicine
Research Summary: Understanding host-pathogen interactions for human and simian immunodeficiency viruses
Portrait Zsuzsanna Fabry, PhD
Pathology and Laboratory Medicine
Research Summary: Mechanisms of neuroinflammation in autoimmunity, infection or traumas of the Central Nervous System.
Nutritional Sciences
Research Summary: Mammalian cellular metabolism is a dynamic process that consists of thousands of interconnected reactions and regulatory interactions. While the architecture of metabolic networks is defined by the genome, actual metabolic activity (i.e. metabolic flux) through the pathways varies greatly. Dynamic reprogramming of metabolism enables cells to meet metabolic needs associated with specific cellular states and cellular functions (such as supporting proliferation or activating immune function), and adapt to changes in the environment. The overarching goal of our research is to understand how mammalian cellular metabolism is reprogrammed in response to changes in the environment and cellular state, and how activities in key metabolic pathways can in turn affect cell function. To study this, we combine systems biology approaches, especially fluxomics and metabolomics, with computational modeling and biochemical and genetic techniques.
Portrait of John O. Fleming, MD
Research Summary: Multiple sclerosis
Portrait of Thomas C. Friedrich, PhD
Pathobiological Sciences
Research Summary: Viral immunity; pathogenesis
Portrait of James E. Gern, MD
Research Summary: To define the role of viral infections in the initiation and disease activity of asthma, and to identify interactions between host and viral factors that determine the severity of respiratory illnesses
Portrait of Thaddeus Golos, MS, PhD
Comparative Biosciences
Research Summary: Placental and endometrial biology, the maternal-fetal interface in health and disease, nonhuman primate embryology and genetic modification for human disease models.
Portrait of Jenny Gumperz, PhD
Medical Microbiology and Immunology
Research Summary: The Gumperz lab studies human innate T lymphocytes, with a particular focus on a subset called Natural Killer T (NKT) cells. NKT cells are able to affect the functions of many other types of immune cells, and in so doing they can markedly influence the outcome of immune responses. Because of this, and because they are activated by conserved antigens, NKT cells are of interest as a human lymphocyte population that could be harnessed clinically for immunotherapeutic strategies. What interests us about NKT cells is that they can become activated by self lipids, which means that they can perform functions even when there is no infectious challenge, and they can amplify immune responses without requiring the presence of a specific foreign antigen. One of the central questions my lab is addressing is to understand how this autoreactivity contributes to inflammatory responses and immune regulation. We are investigating these questions at the molecular and cellular levels, and also in the context of larger immunological processes such as graft-vs-host disease that occurs after transplantation of hematopoietic stem cells, and immune responses during Epstein-Barr virus infection.
Portrait of Peiman Hematti, MD
Research Summary: Bone marrow stem cell biology
Portrait of Anna Huttenlocher, MD
Research Summary: Cell migration and chemotaxis, adhesive mechanisms that regulate cell migration and the role of integrin signaling
Portrait of Shannon Kenney, MD
Research Summary: Understanding the molecular regulation and pathogenesis of the human herpesvirus; Epstein-Barr virus (EBV)
Portrait of Judith Kimble, PhD
Research Summary: The Kimble lab investigates fundamental controls of animal development. Our work takes advantage of the genetic power and cellular simplicity of the nematode Caenorhabditis elegans, which can be viewed as the “E. coli of animal development”. Our findings rely on a variety of experimental strategies and have uncovered genes, proteins and pathways that control development in all animals, including humans.
Portrait of Bruce Klein, MD
Research Summary: The Klein laboratory is a molecular medical mycology research group with two broad areas of focus: fungal pathogenesis and immunology.
Research Summary: Dr. Douglas McNeel, MD PhD is a genitourinary medical oncologist with a translational laboratory research focus on prostate cancer immunology. Since 1997 he and his laboratory have studied vaccines for prostate cancer, specifically identifying antigens to target in vaccines, evaluating DNA vaccines in murine models to elicit tumor-reactive CD8+ T cells, and translating these studies to human clinical trials.
Portrait of Joshua D. Mezrich, MD
Research Summary: Transplant tolerance
Zach Morris
Human Oncology
Research Summary: Immunomodulation of the tumor microenvironment with radiation therapy; novel approaches to in situ cancer vaccination
Portrait of Jeniel Nett, MD. PhD
Research Summary: The host response to biofilm infections, with the goal of devising new approaches for diagnosis and treatment of these common infections.
David O'Connor, PhD
Pathology and Laboratory Medicine
Research Summary: Interactions between host genetics, cellular immunity, and infectious disease pathogenesis, with a primary emphasis on HIV/AIDS.
Portrait of Shelby O'Connor, PhD
Pathology and Laboratory Medicine
Research Summary: Host and vaccine-elicited immune responses to SIV/HIV; Changes to SIV/HIV host immune responses during co-infection with a second pathogen
Portrait of Caitlin S. Pepperell, MD
Research Summary: Bacterial Pathogenesis
Portrait of Federico Eugenio Rey, PhD
Research Summary: Microbiota interactions that impact human health.
Portrait of Lixin Rui, PhD
Research Summary: Investigating the JAK-STAT signaling pathway in lymphoid malignancies; Identifying new molecular targets of this pathway for clinical applications.
Portrait of Matyas Sandor, PhD
Pathology and Laboratory Medicine
Research Summary: Immune responses to infectious disease
Portrait of John-Demian (JD) Sauer, PhD
Medical Microbiology and Immunology
Research Summary: Bacterial Pathogenesis, Innate immunity, Cell Mediated Immunity
Portrait of Chris Seroogy, MD
Research Summary: My research laboratory has had a longstanding interest in the cellular and molecular mechanisms that modify immune responses. My work involves utilization of numerous murine models of T cell unresponsiveness and functional analysis of peripheral blood mononuclear cells from human subjects with a particular interest in allergic inflammation and the contexts that lead to its development. Inspired by our observations that T regulatory (Treg) cells are important during in vivo T cell unresponsiveness in murine models, we turned to human disease states that are the result of imbalanced T cell responses. Our study population is infants and children since the foundation for allergic disease is established early in life.
Portrait of Miriam Shelef, MD, PhD
Research Summary: Rheumatoid arthritis, peptidylarginine deiminases, autoimmunity, inflammation, autoantibodies, neutrophils and other immune cells.
Chemical and Biological Engineering
Research Summary: We are interested in the discovery of novel transport systems and cognate antibody targeting molecules, and we design high throughput selections that serve this purpose. Along these lines, we are also working to optimize the process for producing large amounts of therapeutic antibodies and proteins to meet the eventual demands of clinical application. We are also interested in developing in vitro models of the BBB that accurately mimic the in vivo characteristics of the BBB.
Portrait of Igor Slukvin, MD, PhD
Pathology and Laboratory Medicine
Research Summary: Hematopoietic development from pluripotent stem cells; de novo generation of hematopoietic stem cells, modeling leukemia stem cells using reprogramming technologies
Portrait of Judith A. Smith, MD, PhD
Research Summary: Host-Pathogen interaction and ER stress
Pathobiological Sciences
Research Summary: Molecular and cellular basis of T cell memory; CD8+ T cell responses in chronic viral infections
Portrait of Adel M. Talaat, MVSc, PhD
Pathobiological Sciences
Research Summary: Genomic and functional analyses of tuberculosis and paratuberculosis to understand pathogenesis and develop novel vaccines
Tyler Ulland
Pathology and Laboratory Medicine
Research Summary: The innate immune response to neurodegenerative disease has been understudied until very recently. The Ulland Lab focuses on the role of the innate immune response and more specifically microglial response in AD. We have established the tools and models to effectively work on the neuroimmune response during AD. The ultimate goal of our group is to provide a more thorough understanding of the molecular and metabolic changes in immune cells that precede and follow AD onset, information that will be important in intelligently designing therapeutic strategies.
Portrait of Nathan Welham, PhD
Research Summary: Vocal fold mucosal biology
Portrait of Tim Yoshino, PhD
Pathobiological Sciences
Research Summary: Molecular Parasitology, Schistosomiasis, Parasite-Host Interactions, Mollusc Intermediate Host, Innate Immunity, Pathogen Recognition Receptors, Glycobiology, Neglected Tropical Diseases
Pathobiological Sciences
Research Summary: Host-parasite interactions; Vector-borne parasites; Molecular helminthology; Parasite genomics; Drug discovery; Drug resistance; Receptor biology;