Cancer Biology Trainers

The graduate faculty and a brief statement of their research interests are listed below. Many of these individual research programs are funded by awards from a variety of funding resources. Inquiries regarding space in a laboratory and availability of research support should be directed to the individual faculty member.

Portrait of Nihal Ahmad, PhD
Dermatology
Research Summary: 1) cancer biology, and 2) prevention and experimental therapeutics of cancer
Portrait of Caroline Alexander, PhD
Oncology
Research Summary: Mammary stem cells; Mouse mammary tumor models; Wnt signaling; Syndecan-1
Portrait of Lisa M. Arendt, DVM, PhD
Comparative Biosciences
Research Summary: Breast cancer, tumor/stromal interactions, cancer stem cells, mammary stem cells, Human-in-Mouse Model, inflammation and tumor microenvironment, adipose stem cells
Portrait of Fotis Asimakopoulos, MB, BChir, PhD
Medicine
Research Summary: Myeloma research and phase I experimental therapeutics
Portrait of Emery Bresnick, PhD
Cell and Regenerative Biology
Research Summary: Stem Cell Biology, Epigenetics, Molecular Hematology, Vascular Biology, Cancer Biology: From Fundamental Mechanisms to Translational Medicine
Portrait of Mark Burkard, MD, PhD
Medicine
Research Summary: Breast cancer and drug development
Portrait of Wade Bushman, MD, PhD
Urology
Research Summary: Hedgehog signaling in prostate development and prostate cancer; role of inflammatory signaling in regenerative-repair, hyperplasia and neoplasia; Role of prostate inflammation in producing prostate obstruction and changes in bladder function
Portrait of Christian Capitini, MD
Pediatrics
Research Summary: Using mouse models of allogeneic blood and marrow transplantation (alloBMT) to optimize therapies that prevent graft-versus-host-disease (GVHD) and maximize graft-versus-tumor (GVT) effects
Portrait of Dustin Deming, MD
Medicine
Research Summary: I am a gastrointestinal oncologist at the University of Wisconsin Carbone Cancer Center (UWCCC) and the William S Middleton Veterans Hospital. I have a subspecialty focus in the treatment of colon, rectal and anal cancers. My research aims to fundamentally change the way in which we treat gastrointestinal cancers to a more personalized approach.
Portrait of Loren Clark Denlinger, MD, PhD
Medicine
Research Summary: Host-pathogen interactions; the role of macrophages in immunity to intracellular pathogens; innate immune responses like cytokine production & microbial killing amplified by extracellular nucleotide receptor known as P2X7 (significant functional diversity for this receptor exists between cell types & human subjects); role of P2X7 as candidate gene modulating the human innate immune responses of macrophages & airway epithelial cells to Chlamydia pneumoniae, contribution of responses of asthma
Nutritional Sciences
Research Summary: Mammalian cellular metabolism is a dynamic process that consists of thousands of interconnected reactions and regulatory interactions. While the architecture of metabolic networks is defined by the genome, actual metabolic activity (i.e. metabolic flux) through the pathways varies greatly. Dynamic reprogramming of metabolism enables cells to meet metabolic needs associated with specific cellular states and cellular functions (such as supporting proliferation or activating immune function), and adapt to changes in the environment. The overarching goal of our research is to understand how mammalian cellular metabolism is reprogrammed in response to changes in the environment and cellular state, and how activities in key metabolic pathways can in turn affect cell function. To study this, we combine systems biology approaches, especially fluxomics and metabolomics, with computational modeling and biochemical and genetic techniques.
Portrait of Andreas Friedl, MD
Pathology and Laboratory Medicine
Research Summary: Tumor-stroma interactions; heparan sulfate proteoglycans in cancer.
Portrait of Daniel S. Greenspan, PhD
Cell and Regenerative Biology
Research Summary: Extracellular modulators of cellular behaviors in development, homeostasis, and disease
Portrait of Jenny Gumperz, PhD
Medical Microbiology and Immunology
Research Summary: The Gumperz lab studies human innate T lymphocytes, with a particular focus on a subset called Natural Killer T (NKT) cells. NKT cells are able to affect the functions of many other types of immune cells, and in so doing they can markedly influence the outcome of immune responses. Because of this, and because they are activated by conserved antigens, NKT cells are of interest as a human lymphocyte population that could be harnessed clinically for immunotherapeutic strategies. What interests us about NKT cells is that they can become activated by self lipids, which means that they can perform functions even when there is no infectious challenge, and they can amplify immune responses without requiring the presence of a specific foreign antigen. One of the central questions my lab is addressing is to understand how this autoreactivity contributes to inflammatory responses and immune regulation. We are investigating these questions at the molecular and cellular levels, and also in the context of larger immunological processes such as graft-vs-host disease that occurs after transplantation of hematopoietic stem cells, and immune responses during Epstein-Barr virus infection.
Portrait of Richard Halberg, PhD
Medicine
Research Summary: Tumors are often heterogeneous with respect to many features. My research focuses on identifying sources of heterogeneity and determining how such heterogeneity impacts prevention and treatment. Novel concepts are being tested with a unique experimental platform consisting of recently developed animal models and state-of-the-art imaging. The results could potentially shift current paradigms in cancer biology.
Human Oncology
Research Summary: 1. Genomics and Molecular Imaging of Lung-Brain Metastasis 2. Defining the functional significance of bromodomain containing proteins in pan-cancer studies.
Cell and Regenerative Biology
Research Summary: The capacity for complex tissue regeneration is unevenly distributed across species. Unlike human, zebrafish possess a remarkable potential to regenerate tissues such as amputated appendages and damaged heart muscles. Interest of my laboratory is to understand how and what genetic and epigenetic factors control tissue regeneration using adult zebrafish as a model system.
Portrait of Shannon Kenney, MD
Oncology
Research Summary: Understanding the molecular regulation and pathogenesis of the human herpesvirus; Epstein-Barr virus (EBV)
Portrait of Dudley Lamming, PhD
Medicine
Research Summary: The Lamming laboratory's goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity.
Medicine
Research Summary: Cancer resistance Assay and biomarker development Drug development for solid tumors
Biomolecular Chemistry
Research Summary: Chromatin Dynamics in Development and Cancer
Portrait of Ricardo V. Lloyd, MD, PhD
Pathology and Laboratory Medicine
Research Summary: Thyroid cancer stem cells, Neuroendocrine tumors, Pituitary tumors
Portrait of Daniel D. Loeb, PhD
Oncology
Research Summary: molecular biology of the hepatitis B viruses
Medicine
Research Summary: Dr. Douglas McNeel, MD PhD is a genitourinary medical oncologist with a translational laboratory research focus on prostate cancer immunology. Since 1997 he and his laboratory have studied vaccines for prostate cancer, specifically identifying antigens to target in vaccines, evaluating DNA vaccines in murine models to elicit tumor-reactive CD8+ T cells, and translating these studies to human clinical trials.
Zach Morris
Human Oncology
Research Summary: Immunomodulation of the tumor microenvironment with radiation therapy; novel approaches to in situ cancer vaccination
Portrait of Deane Mosher, MD
Biomolecular Chemistry
Research Summary: Extracellular matrix; cell adhesion
Portrait of Mario Otto, MD, PhD
Pediatrics
Research Summary: The overall goal of my laboratory and translational research is the development of targeted therapies and immunotherapies to improve patient survival while reducing short- and long-term side effects from largely untargeted conventional chemotherapies. Currently, my laboratory focuses on three major areas in targeted cancer therapies.
Pathology and Laboratory Medicine
Research Summary: Cell-matrix signaling in the human eye; glaucoma
Portrait of Alan C. Rapraeger, PhD
Human Oncology
Research Summary: Cell surface proteoglycans, heparin-binding growth factors
Portrait of Lixin Rui, PhD
Medicine
Research Summary: Investigating the JAK-STAT signaling pathway in lymphoid malignancies; Identifying new molecular targets of this pathway for clinical applications.
Medicine
Research Summary: Molecular regulation of the coagulation serine proteases; novel therapeutic targets for antithrombotic therapy; mechanisms for hormone-induced and cancer-associated thrombosis.
Portrait of Paul Sondel, MD, PhD
Pediatrics
Research Summary: Cell Mediated Tumor Destruction: Efficacy and Escape
Oncology
Research Summary: Molecular biology of the human tumor virus, Epstein-Barr virus
Portrait of Deric L. Wheeler, PhD
Human Oncology
Research Summary: Mechanisms of resistance to targeted therapies
Portrait of Wei Xu, PhD
Oncology
Research Summary: My lab works on understanding the progression of estrogen dependent and independent breast cancers and identifying novel therapeutic targets for personalized cancer treatment.
Portrait of Weixiong Zhong, MD, PhD
Pathology and Laboratory Medicine
Research Summary: Oxidative stress and redox regulation in carcinogenesis and cancer chemoprevention