Federico Eugenio Rey, PhD

Portrait of Federico Eugenio Rey, PhD
Assistant Professor
Bacteriology
Address: 
5157 Microbial Sciences
1550 Linden Dr
Madison, WI 53706
Telephone: 
(608) 890-2046
Focus Groups: 
Immunology/Immunopathology
Education: 
PhD, Microbiology, University of Iowa
BS, MS, Clinical Chemistry, Universidad Nacional de Cordoba
Postdoctoral, Microbiology, Washington University, St. Louis, MO
Research Summary: 
Microbiota interactions that impact human health.
Research Detail: 

Humans harbor large microbial communities in the gastrointestinal tract. This collection of microbes (microbiota) and their associated genes (microbiome) affect many aspects of our physiology. Host diet determines gut microbial metabolism, which in turn modifies the nutritional impact of many dietary components. Thus, in principle, the gut microbiota can be targeted through diet to promote health. However, to successfully manipulate this microbial bioreactor, we need to understand how microbes metabolize nutrients, how they interact with each other as a function of diet, and their impact on the host. The overall goal of our research is to dissect diet by microbiota interactions that impact human health, so that therapeutic/preventive dietary recommendations can be made based on the metabolic potential of a subject’s microbiome.

Gut microbial metabolism of specific dietary components (e.g., choline, flavonoids) generates compounds that can impact cardiovascular diseases. The microbes responsible for such transformations and their representation in humans remain poorly characterized. Projects in my lab aim at identifying human gut bacterial species that transform some of these compounds, the genes involved in these processes, their regulation and their impact in the development of cardiovascular disease. Towards this end, we are using gnotobiotic mouse models of cardiovascular disease, bacterial genetics, transcriptional profiling and metabolomics.

Selected Publications: 
Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, et al., 2013. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 341: 1241214. (PMC in process)
Rey FE*, Gonzalez M*, Cheng J, Wu M, Gordon JI. Metabolic niche of a prominent sulfate-reducing human gut bacterium. Proc Natl Acad Sci 110: 13582-7. (PMC3746858) * contributed equally
Pluznick J, Protzko RJ, Haykanush G, Peterlin Z, Sipos A, Han J, Brunet I, Rey FE, Wang T, Firestein S, Yanagisawa M, Gordon JI, Eichmann A, Peti-Peterdi J, Caplan MJ. 2013. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. Proc Natl Acad Sci 110: 4410-15. (PMC3600440)
Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC, Warner B, Reeder J, Kuczynski J, Lozupone CA, Lauber C, Clemente JC, Knights D, Knight R, Gordon JI. 2012. Human gut microbiome differentiation viewed across cultures, ages and families. Nature 486: 222–7.(PMC3376388)
Wei X, Yang Z, Rey FE, Ridaura V, Davidson NO, Gordon JI, Semenkovich C. 2012. Fatty Acid Synthase Modulates Intestinal Barrier Function through Palmitoylation of Mucin 2. Cell Host & Microbe 11: 140-52.(PMC3285413)
Faith JJ, McNulty NP, Rey FE, Gordon JI. 2011. Predicting a human gut microbiota's response to diet in gnotobiotic mice. Science 333: 101-4. (PMC3303606)
Rey FE*, Faith JJ*, Bain J, Muehlbauer MJ, Stevens RD, Newgard CB, Gordon JI. 2010. Dissecting the in vivo metabolic potential of two human gut acetogens. J Biol Chem 285: 22082 90.(PMC2903421) * contributed equally
Faith JJ*, Rey FE*, O'Donnell D, Karlsson M, McNulty NP, Kallstrom G, Goodman AL, Gordon JI. 2010. Creating and characterizing communities of human gut microbes in gnotobiotic mice. ISME J 4 :1094-8. (PMC2927777) * contributed equally
Rey FE, Harwood CS. 2010. FixK, a global regulator of microaerobic growth, controls photosynthesis in Rhodopseudomonas palustris. Mol Microbiol 75: 1007–20.
Mahowald M*, Rey FE*, Seedorf H, Turnbaugh PJ, Fulton RS et al. 2009. Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proc Natl Acad Sci 106: 5859-64.(PMC2660063) * contributed equally
Rey FE, Heniger E , Harwood CS. 2007. Redirection of metabolism for biological hydrogen production by Rhodopseudomonas palustris. Appl Environ Microbiol 73: 1665-71. (PMC1828789)
Rey, FE, Oda Y, Harwood CS. 2006. Regulation of uptake hydrogenase and effects of hydrogen utilization on gene expression in Rhodopseudomonas palustris. J Bacteriol 188 (17):6143-52. (PMC1595397)
Rey FE, Pagano PJ. 2002. The reactive adventitia: fibroblast oxidase in vascular function. Arterioscler Thromb Vasc Bio 22 (12):1962-71. Program Director/Principal Investigator (Rey, Federico, Eugenio):
Rey FE, Li X, Garvin JL, Pagano PJ. 2002. Perivascular superoxide anion contributes to impairment of endothelium-dependent relaxation: role of gp91phox. Circulation 106 (19):2497-502.
Rey FE, Cifuentes ME, Quinn MT, Pagano PJ. 2001. Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O2 - and systolic blood pressure in mice. Circ Res 89 (5):408-14.