Federico Eugenio Rey, PhD

Portrait of Federico Eugenio Rey, PhD
Assistant Professor
Bacteriology
Address: 
5157 Microbial Sciences
1550 Linden Dr
Madison, WI 53706
Telephone: 
(608) 890-2046
Focus Groups: 
Immunology/Immunopathology
Education: 
PhD, Microbiology, University of Iowa
BS, MS, Clinical Chemistry, Universidad Nacional de Cordoba
Postdoctoral, Microbiology, Washington University, St. Louis, MO
Research Summary: 
Microbiota interactions that impact human health.
Research Detail: 

Humans harbor large microbial communities in the gastrointestinal tract. This collection of microbes (microbiota) and their associated genes (microbiome) affect many aspects of our physiology. Host diet determines gut microbial metabolism, which in turn modifies the nutritional impact of many dietary components. Thus, in principle, the gut microbiota can be targeted through diet to promote health. However, to successfully manipulate this microbial bioreactor, we need to understand how microbes metabolize nutrients, how they interact with each other as a function of diet, and their impact on the host. The overall goal of our research is to dissect diet by microbiota interactions that impact human health, so that therapeutic/preventive dietary recommendations can be made based on the metabolic potential of a subject’s microbiome.

Gut microbial metabolism of specific dietary components (e.g., choline, flavonoids) generates compounds that can impact cardiovascular diseases. The microbes responsible for such transformations and their representation in humans remain poorly characterized. Projects in my lab aim at identifying human gut bacterial species that transform some of these compounds, the genes involved in these processes, their regulation and their impact in the development of cardiovascular disease. Towards this end, we are using gnotobiotic mouse models of cardiovascular disease, bacterial genetics, transcriptional profiling and metabolomics.

Selected Publications: 
A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice.Yang H, Wang W, Romano KA, Gu M, Sanidad KZ, Kim D, Yang J, Schmidt B, Panigrahy D, Pei R, Martin DA, OzayEI, Wang Y, Song M, Bolling BW, Xiao H, Minter LM, Yang GY, Liu Z, Rey FE, Zhang G.Sci Transl Med. 2018 May 30;10(443). pii: eaan4116. doi: 10.1126/scitranslmed.aan4116.PMID: 29848663
Fecal Aliquot Straw Technique (FAST) allows for easy and reproducible subsampling: assessing interpersonal variation in trimethylamine-N-oxide (TMAO) accumulation.Romano KA, Dill-McFarland KA, Kasahara K, Kerby RL, Vivas EI, Amador-Noguez D, Herd P, Rey FE.Microbiome. 2018 May 18;6(1):91. doi: 10.1186/s40168-018-0458-8.PMID: 29776435
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.Li XS, Wang Z, Cajka T, Buffa JA, Nemet I, Hurd AG, Gu X, Skye SM, Roberts AB, Wu Y, Li L, Shahen CJ, Wagner MA, Hartiala JA, Kerby RL, Romano KA, Han Y, Obeid S, Lüscher TF, Allayee H, Rey FE, DiDonato JA, Fiehn O, Tang WHW, Hazen SL.JCI Insight. 2018 Mar 22;3(6). pii: 99096. doi: 10.1172/jci.insight.99096. [Epub ahead of print]PMID: 29563342
Gut microbiome alterations in Alzheimer's disease.Vogt NM, Kerby RL, Dill-McFarland KA, Harding SJ, Merluzzi AP, Johnson SC, Carlsson CM, Asthana S, Zetterberg H,Blennow K, Bendlin BB, Rey FE.Sci Rep. 2017 Oct 19;7(1):13537. doi: 10.1038/s41598-017-13601-y.PMID: 29051531
Metabolic, Epigenetic, and Transgenerational Effects of GutBacterial Choline Consumption.Romano KA, Martinez-Del Campo A, Kasahara K, Chittim CL, Vivas EI, Amador-Noguez D, Balskus EP, Rey FE.Cell Host Microbe. 2017 Sep 13;22(3):279-290.e7. doi: 10.1016/j.chom.2017.07.021. Epub 2017 Aug 24.PMID: 28844887
The Influence of Social Conditions Across the Life Course on the Human Gut Microbiota: A Pilot Project With the Wisconsin Longitudinal Study.Herd P, Schaeffer NC, DiLoretoK, JacquesK, Stevenson J, Rey F, Roan C.J Gerontol B Psychol Sci Soc Sci. 2017 Dec 15;73(1):124-133. doi: 10.1093/geronb/gbx029.PMID: 28444239
Chemical signaling between gut microbiota and host chromatin: What is your gut really saying?Krautkramer KA, Rey FE, Denu JM.J Biol Chem. 2017 May 26;292(21):8582-8593. doi: 10.1074/jbc.R116.761577. Epub 2017 Apr 7. Review.PMID: 28389558
Host Genotype and Gut Microbiome Modulate Insulin Secretion and Diet-Induced Metabolic Phenotypes.Kreznar JH, Keller MP, Traeger LL, Rabaglia ME, Schueler KL, Stapleton DS, Zhao W, Vivas EI, Yandell BS, Broman AT,Hagenbuch B, Attie AD, Rey FE.Cell Rep. 2017 Feb 14;18(7):1739-1750. doi: 10.1016/j.celrep.2017.01.062.PMID: 28199845
Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues.Krautkramer KA, Kreznar JH, Romano KA, Vivas EI, Barrett-Wilt GA, Rabaglia ME, KellerMP, Attie AD, Rey FE, Denu JM.Mol Cell. 2016 Dec 1;64(5):982-992. doi: 10.1016/j.molcel.2016.10.025. Epub2016 Nov 23.PMID: 27889451
The Plot Thickens: Diet Microbe Interactions May Modulate Thrombosis Risk.Martínez-Del Campo A,Romano KA, Rey FE, Balskus EP.Cell Metab. 2016 Apr 12;23(4):573-5. doi: 10.1016/j.cmet.2016.03.017.PMID: 27076072