Emery Bresnick, PhD

Portrait of Emery Bresnick, PhD
Professor
Cell and Regenerative Biology
Address: 
4009 WIMR
1111 Highland Ave
Madison, WI 53705
Telephone: 
(608) 265-6446
Focus Groups: 
Cancer Biology
Signal Transduction
Education: 
PhD, Pharmacology, The University of Michigan Medical School
Postdoctoral, National Institutes of Health, Laboratory of Molecular Biology
Research Summary: 
Stem Cell Biology, Epigenetics, Molecular Hematology, Vascular Biology, Cancer Biology: From Fundamental Mechanisms to Translational Medicine
Research Detail: 

We use multidisciplinary approaches to understand normal and malignant blood cell development/function (hematopoiesis), gene/chromosome regulation (including epigenetics), and vascular biology. Our team has expertise in genomics, proteomics, chemical genetics, and computational analysis, as well as powerful molecular, cellular, and biochemical science.

A major effort involves discovering mechanisms that regulate the genesis and function of hematopoietic stem and progenitor cells. Defining such mechanisms has enormous importance, as their disruption leads to the development of adult and pediatric blood cell cancers (leukemias, lymphomas, myelodysplastic syndrome) and additional blood cell disorders, including immunodeficiency. While hematopoietic stem cells are routinely transplanted to treat diverse diseases, their critical long-term repopulating activity is poorly understood and cannot be readily modulated for therapeutic application. Mechanistic insights can be exploited to develop novel approaches to therapeutically modulate hematopoietic stem cells, hematopoiesis, and blood cell malignancies.

Another program focuses on the transcriptional/epigenetic control of red blood cell development and function. Goals of this work include discovering the cause of red blood cell disorders, including anemias and hemoglobinopathies, developing translational strategies, and advancing fundamental knowledge in broadly important areas of biomedical science.

Since GATA-2 controls the emergence of hematopoietic stem cells from hemogenic endothelium, angiogenesis, vascular integrity, and developmental of the lymphatic system, we are studying how GATA-2 functions in the vascular system in normal and pathophysiological states.

Dr. Bresnick and his team are passionate about making biological and mechanistic discoveries, translating such discoveries into clinical insights and strategies, and training the next-generation of multidisciplinary researchers/scholars (undergraduates, graduate students, postdoctoral fellows).

Interested candidates can apply to:  ehbresni@wisc.edu

Selected Publications: 
Polycomb Group Protein YY1 Is an Essential Regulator of Hematopoietic Stem Cell Quiescence. Lu Z, Hong CC, Kong G, Assumpção ALFV, Ong IM, Bresnick EH, Zhang J, Pan X. Cell Rep. 2018 Feb 6;22(6):1545-1559. doi: 10.1016/j.celrep.2018.01.026. PMID: 29425509
Mechanisms of erythrocyte development and regeneration: implications for regenerative medicine and beyond. Bresnick EH, Hewitt KJ, Mehta C, Keles S, Paulson RF, Johnson KD. Development. 2018 Jan 10;145(1). pii: dev151423. doi: 10.1242/dev.151423. Review. PMID: 29321181
Dissecting Regulatory Mechanisms Using Mouse Fetal Liver-Derived Erythroid Cells. McIver SC, Hewitt KJ, Gao X, Mehta C, Zhang J, Bresnick EH. Methods Mol Biol. 2018;1698:67-89. doi: 10.1007/978-1-4939-7428-3_4. PMID: 29076084
Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program. Mehta C, Johnson KD, Gao X, Ong IM, Katsumura KR, McIver SC, Ranheim EA, Bresnick EH. Cell Rep. 2017 Sep 19;20(12):2966-2979. doi: 10.1016/j.celrep.2017.08.090. PMID: 28930689
GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia. Hewitt KJ, Katsumura KR, Matson DR, Devadas P, Tanimura N, Hebert AS, Coon JJ, Kim JS, Dewey CN, Keles S, Hao S, Paulson RF, Bresnick EH. Dev Cell. 2017 Aug 7;42(3):213-225.e4. doi: 10.1016/j.devcel.2017.07.009. PMID: 28787589
The GATA factor revolution in hematology. Katsumura KR, Bresnick EH; GATA Factor Mechanisms Group. Blood. 2017 Apr 13;129(15):2092-2102. doi: 10.1182/blood-2016-09-687871. Epub 2017 Feb 8. Review. PMID: 28179282
p53-/-synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia. Zhang J, Kong G, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E, Zhang J. Blood. 2017 Jan 19;129(3):358-370. doi: 10.1182/blood-2016-06-719237. Epub 2016 Nov 4. PMID: 27815262
GATA Factor-Dependent Positive-Feedback Circuit in Acute Myeloid Leukemia Cells. Katsumura KR, Ong IM, DeVilbiss AW, Sanalkumar R, Bresnick EH. Cell Rep. 2016 Aug 30;16(9):2428-41. doi: 10.1016/j.celrep.2016.07.058. Epub 2016 Aug 18. PMID: 27545880
Exosome complex orchestrates developmental signaling to balance proliferation and differentiation during erythropoiesis. McIver SC, Katsumura KR, Davids E, Liu P, Kang YA, Yang D, Bresnick EH. Elife. 2016 Aug 20;5. pii: e17877. doi: 10.7554/eLife.17877. PMID: 27543448
Integrative analysis with ChIP-seq advances the limits of transcript quantification from RNA-seq.Liu P, Sanalkumar R, Bresnick EH, Keleş S, Dewey CN.Genome Res. 2016 Aug;26(8):1124-33. doi: 10.1101/gr.199174.115. Epub 2016 Jul 12.PMID: 27405803