Dudley Lamming, PhD

Portrait of Dudley Lamming, PhD
Assistant Professor
Medicine
Address: 
2500 Overlook Terr
VAH C3127 Res 151
Madison, WI 53705
Telephone: 
(608) 256-1901 x12861
Focus Groups: 
Cancer Biology
Signal Transduction
Education: 
PhD, Harvard University
BS, Massachusetts Institute of Technology
Research Summary: 
The Lamming laboratory's goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity.
Research Detail: 

The Lamming laboratory's goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. We are primarily focused on the physiological role played by the mechanistic target of rapamycin (mTOR), a protein kinase that through a diverse set of substrates regulates complex cellular processes, including growth, metabolism, and aging. Recent work has shown that rapamycin, an inhibitor of mTOR signaling, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions in mouse models may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer's disease, cancer, and Hutchinson-Gilford Progeria Syndrome.

Selected Publications: 
Short-term methionine deprivation improves metabolic health via sexually dimorphic,mTORC1-independent mechanisms.Yu D, Yang SE, Miller BR, Wisinski JA, Sherman DS, Brinkman JA, Tomasiewicz JL, Cummings NE, Kimple ME, Cryns VL, Lamming DW.FASEB J. 2018 Jun;32(6):3471-3482. doi: 10.1096/fj.201701211R. Epub 2018 Jan 30.PMID: 29401631
Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice.Lamming DW, Baar EL, Arriola Apelo SI, Tosti V, Fontana L.Nutr Healthy Aging. 2017 Dec 7;4(3):239-245. doi: 10.3233/NHA-170025.PMID: 29276793
Restoration of metabolic health by decreased consumptionof branched-chain amino acids.Cummings NE, Williams EM, Kasza I, Konon EN, Schaid MD, Schmidt BA, Poudel C, Sherman DS, Yu D, Arriola Apelo SI, Cottrell SE, Geiger G, Barnes ME, Wisinski JA, Fenske RJ, Matkowskyj KA, Kimple ME, AlexanderCM, Merrins MJ, Lamming DW.J Physiol. 2018 Feb 15;596(4):623-645. doi: 10.1113/JP275075. Epub 2017 Dec 27.PMID: 29266268
SYK kinase mediates brown fat differentiation and activation.Knoll M, Winther S, Natarajan A, Yang H, Jiang M, Thiru P, Shahsafaei A, Chavarria TE, Lamming DW, Sun L, Hansen JB, Lodish HF.Nat Commun. 2017 Dec 13;8(1):2115. doi: 10.1038/s41467-017-02162-3.PMID: 29235464
STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.Moretti J, Roy S, Bozec D, Martinez J, Chapman JR, Ueberheide B, Lamming DW, Chen ZJ, Horng T, Yeretssian G, Green DR, Blander JM.Cell. 2017 Nov 2;171(4):809-823.e13. doi: 10.1016/j.cell.2017.09.034. Epub 2017 Oct 19.PMID: 29056340
Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy.Linnemann AK, Blumer J, Marasco MR, Battiola TJ, Umhoefer HM, Han JY, Lamming DW, Davis DB.FASEB J. 2017 Sep;31(9):4140-4152. doi: 10.1096/fj.201700061RR. Epub 2017 Jun 7.PMID: 28592636
Neuropeptide FF increases M2 activation and self-renewalof adipose tissue macrophages.Waqas SFH, Hoang AC, Lin YT, Ampem G, Azegrouz H, Balogh L, Thuróczy J, Chen JC, Gerling IC, Nam S, Lim JS, Martinez-Ibañez J, Real JT, Paschke S, Quillet R, Ayachi S, Simonin F, Schneider EM, Brinkman JA, Lamming DW, Seroogy CM, Röszer T.J Clin Invest. 2017 Jun 30;127(7):2842-2854. doi: 10.1172/JCI90152. Epub2017 Jun 5.PMID: 28581443
Regulation of metabolic health and aging by nutrient-sensitive signaling pathways.Cummings NE, Lamming DW.Mol Cell Endocrinol. 2017 Nov 5;455:13-22. doi: 10.1016/j.mce.2016.11.014. Epub 2016 Nov 22. Review.PMID: 27884780
mTORC2 Puts Its Shoulder to Krebs' Wheel.Arriola Apelo SI, Lamming DW.Mol Cell. 2016 Sep 1;63(5):723-5. doi: 10.1016/j.molcel.2016.08.016.PMID: 27588599