Bo Liu, PhD

Portrait of Bo Liu, PhD
Associate Professor
Surgery
Address: 
5137 WIMR
1111 Highland Ave
Madison, WI 53705
Telephone: 
(608) 263-5931
Focus Groups: 
Signal Transduction
Education: 
PhD, Biochemistry, SUNY Downstate
Research Summary: 
Vascular diseases, cell apoptosis, inflammation, signaling, adult progenitor cells, gene therapy
Research Detail: 

A major research goal of Liu’s lab is to understand the pathophysiology of vascular disease including atherosclerosis, restenosis (intimal hyperplasia) and abdominal aortic aneurysms. Using a combination of molecular, biochemical and genetic approaches, Dr. Liu and her co-investigators identified several intracellular signaling proteins that are critical in regulation of vascular smooth muscle cells, endothelial cells, fibroblasts and progenitor cells. Current research topics include interaction between smooth muscle cell apoptosis and vascular inflammation, progenitor cell recruitment and differentiation, signaling pathways underlying apoptosis, migration, cytokine expression and other functions of smooth muscle cells. Additional research interests are gene therapy and nanotechnology. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, who has created a lab environment that fosters creative thinking, multidisciplinary approaches, independence, and collaboration.

Selected Publications: 
Necroptosis in cardiovascular disease -a new therapeutic target.Gupta K, Phan N, Wang Q, Liu B.J Mol Cell Cardiol. 2018 May;118:26-35. doi: 10.1016/j.yjmcc.2018.03.003. Epub 2018 Mar 7. Review.PMID: 29524460
DNA Barcode Authentication and Library Development for the Wood of Six Commercial Pterocarpus Species: the Critical Role of Xylarium Specimens.Jiao L, Yu M, Wiedenhoeft AC, He T, Li J, Liu B, Jiang X, Yin Y.Sci Rep. 2018 Jan 31;8(1):1945. doi: 10.1038/s41598-018-20381-6.PMID: 29386565
Periadventitial drug delivery for the prevention of intimal hyperplasia following open surgery.Chaudhary MA, Guo LW, Shi X, Chen G, Gong S, Liu B, Kent KC.J Control Release. 2016 Jul 10;233:174-80. doi: 10.1016/j.jconrel.2016.05.002. Epub 2016 May 12. Review.PMID: 27179635
Preferential secretion of collagen type 3 versus type 1 from adventitial fibroblasts stimulated by TGF-β/Smad3-treated medial smooth muscle cells.Goel SA, Guo LW, Shi XD, Kundi R, Sovinski G, SeedialS, Liu B, Kent KC.Cell Signal. 2013 Apr;25(4):955-60. doi: 10.1016/j.cellsig.2012.12.021. Epub 2012 Dec 29.PMID: 23280188
Reduction of intimal hyperplasia in injured rat arteries promoted by catheter balloons coated with polyelectrolyte multilayers that contain plasmid DNA encoding PKCδ.Bechler SL, Si Y, Yu Y, Ren J, Liu B, Lynn DM.Biomaterials. 2013 Jan;34(1):226-36. doi: 10.1016/j.biomaterials.2012.09.010. Epub 2012 Oct 13.PMID: 23069712
Mechanisms of post-intervention arterial remodelling.GoelSA, Guo LW, Liu B, Kent KC.Cardiovasc Res. 2012 Dec 1;96(3):363-71. doi: 10.1093/cvr/cvs276. Epub 2012 Aug 22. Review.PMID: 22918976
Elevated protein kinase C-δ contributes to aneurysm pathogenesis through stimulation of apoptosis and inflammatory signaling.Morgan S, Yamanouchi D, Harberg C, Wang Q, Keller M, Si Y, Burlingham W, Seedial S, Lengfeld J, Liu B.Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2493-502. doi: 10.1161/ATVBAHA.112.255661. Epub 2012 Aug 9.PMID: 22879584
Protein kinase C δ regulates the release of collagen type I from vascular smooth musclecells via regulation of Cdc42.Lengfeld J, Wang Q, Zohlman A, Salvarezza S, Morgan S, Ren J, Kato K, Rodriguez-Boulan E, Liu B.Mol Biol Cell. 2012 May;23(10):1955-63. doi: 10.1091/mbc.E11-06-0531. Epub 2012 Mar 28.PMID: 22456512
Delivery of plasmid DNA to vascular tissue in vivo using catheter balloons coated with polyelectrolyte multilayers.Saurer EM, Yamanouchi D, Liu B, Lynn DM.Biomaterials. 2011 Jan;32(2):610-8. doi: 10.1016/j.biomaterials.2010.09.009. Epub 2010 Oct 8.PMID: 20933275
Imaging of Abdominal Aortic Aneurysm: the present and the future.Hong H, Yang Y, Liu B, Cai W.Curr Vasc Pharmacol. 2010 Nov;8(6):808-19. Review.PMID: 20180767