Andreas Friedl, MD

Portrait of Andreas Friedl, MD
Department Chair
Pathology and Laboratory Medicine
6051 WIMR
1111 Highland Ave
Madison, WI 53705
(608) 265-9283
Focus Groups: 
Cancer Biology
Signal Transduction
Dr. of Medicine (Dr. med.), University of Erlangen, Germany
MD, University of Erlangen, Germany
Research Summary: 
Tumor-stroma interactions; heparan sulfate proteoglycans in cancer.
Research Detail: 

My research focuses on the role of heparan sulfate proteoglycans (HSPGs) in tumorigenesis and cancer progression. HSPGs are hybrid molecules, which consist of core proteins and heparin-like polysaccharide domains. HSPGs are found in abundance on cell surfaces and in the extracellular matrix. One project focuses on the role of the HSPG syndecan-1 in stromal fibroblasts of breast carcinomas. The goal is to decipher the mechanisms by which stromal syndecan-1 stimulates breast carcinoma growth and invasion. A separate project aims at identifying the mechanisms by which the HSPG glypican-1 regulates cell cycle progression in brain tumor cells.

Selected Publications: 
Antiestrogen Therapy Increases Plasticity and Cancer Stemness of Prolactin-Induced ERα+ Mammary Carcinomas. Shea MP, O'Leary KA, Fakhraldeen SA, Goffin V, Friedl A, Wisinski KB, Alexander CM, Schuler LA. Cancer Res. 2018 Apr 1;78(7):1672-1684. doi: 10.1158/0008-5472.CAN-17-0985. Epub 2018 Jan 23. PMID: 29363543
Collagen Alignment as a Predictor of Recurrence after Ductal Carcinoma In Situ. Conklin MW, Gangnon RE, Sprague BL, Van Gemert L, Hampton JM, Eliceiri KW, Bredfeldt JS, Liu Y, Surachaicharn N, Newcomb PA, Friedl A, Keely PJ, Trentham-Dietz A. Cancer Epidemiol Biomarkers Prev. 2018 Feb;27(2):138-145. doi: 10.1158/1055-9965.EPI-17-0720. Epub 2017 Nov 15. PMID: 29141852
Retraction for Qiao et al., Glypican 1 Stimulates S Phase Entry and DNA Replication in Human Glioma Cells and Normal Astrocytes. Qiao D, Meyer K, Friedl A. Mol Cell Biol. 2016 Jul 14;36(15):2105. doi: 10.1128/MCB.00321-16. Print 2016 Aug 1. No abstract available. PMID: 27418536
Syndecan-1-Induced ECM Fiber Alignment Requires Integrin αvβ3 and Syndecan-1 Ectodomain and Heparan Sulfate Chains. Yang N, Friedl A. PLoS One. 2016 Feb 24;11(2):e0150132. doi: 10.1371/journal.pone.0150132. eCollection 2016 PMID: 26909794
A positive feedback loop between prolactin and STAT5 promotes angiogenesis. Yang X, Friedl A. Adv Exp Med Biol. 2015;846:265-80. doi: 10.1007/978-3-319-12114-7_12. Review. PMID: 25472543
Understanding the impact of 2D and 3D fibroblast cultures on in vitro breast cancer models. Sung KE, Su X, Berthier E,Pehlke C, Friedl A, Beebe DJ. PLoS One. 2013 Oct 4;8(10):e76373. doi: 10.1371/journal.pone.0076373. eCollection 2013. PMID: 24124550
STAT5 and prolactin participate in a positive autocrine feedback loop that promotes angiogenesis. Yang X, Meyer K, Friedl A. J Biol Chem. 2013 Jul 19;288(29):21184-96. doi: 10.1074/jbc.M113.481119. Epub 2013 Jun 2. PMID: 23729680
Normal mammary fibroblasts induce reversion of the malignant phenotype in human primary breast cancer. Römer AM, Lühr I, Klein A, Friedl A, Sebens S, Rösel F, Arnold N, Strauss A, Jonat W, Bauer M. Anticancer Res. 2013 Apr;33(4):1525-36. PMID: 23564794
Functional screen of paracrine signals in breast carcinoma fibroblasts. Su G, Sung KE, Beebe DJ, Friedl A. PLoS One. 2012;7(10):e46685. doi: 10.1371/journal.pone.0046685. Epub 2012 Oct 8. Erratum in: PLoS One. 2013;8(4). doi:10.1371/annotation/c5015b96-51d1-4421-8b48-d2478b947959. PMID: 23056402
Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical andparacrine signals. Lühr I, Friedl A, Overath T, Tholey A, Kunze T, Hilpert F, Sebens S, Arnold N, Rösel F, Oberg HH, Maass N, Mundhenke C, Jonat W, Bauer M. Cancer Lett. 2012 Dec 28;325(2):175-88. doi: 10.1016/j.canlet.2012.06.014. Epub 2012 Jul 7. PMID: 22776560