Ahmed I. Mahmoud, Ph.D.

Assistant Professor
Cell and Regenerative Biology
Address: 
4557 WIMR II
1111 Highland Avenue
Madison, WI 53705
Telephone: 
(608) 262-8682
Focus Groups: 
Neuroscience/Neuropathology
Signal Transduction
Education: 
PhD, University of Texas Southwestern Medical Center
Postdoctoral Fellowship, Harvard University
Research Summary: 
Cardiac regeneration, Transcriptional control of cardiomyocyte cell cycle, Nerve regulation of heart regeneration
Research Detail: 

Heart failure is the leading cause of death in the world due to the inability of the adult mammalian heart to regenerate following injury. Lower vertebrates, such as zebrafish are capable of complete and efficient regeneration of the myocardium following injury. Similarly, we demonstrated that neonatal mice are capable of regenerating their hearts within a short period after birth but lose this potential in the first week of life. Adult mammals lack this cardiac regeneration potential, thus our overarching goal in the laboratory is to dissect the molecular underpinnings of regeneration in the neonatal heart so that we can explore potential avenues to activate this process in adult humans.

Our goals are to identify the transcriptional and epigenetic networks that govern cardiomyocyte dedifferentiation and proliferation during regeneration. These studies could aid in converting adult cardiomyocytes to a more proliferative and regenerative state. In addition, we aim to identify the microenvironment signals that regulate mammalian heart regeneration by studying the interplay of nerves as well as extracellular factors during mammalian heart regeneration. We use multidisciplinary approaches including genomics, proteomics, and mouse genetics in addition to molecular and cellular technologies to address these questions.

 

Selected Publications: 
A Breakdown in Cooperativity Leads to Cardiac Identity Crisis.Vujic A, Mahmoud AI, Lee RT.Cell. 2016 Dec 15;167(7):1674-1676. doi: 10.1016/j.cell.2016.11.056.PMID: 27984717
Adrenergic function restoration in the transplanted heart: a role for neural crest-derived cells.Mahmoud AI, Lee RT.Cardiovasc Res. 2016 Mar 1;109(3):348-9. doi: 10.1093/cvr/cvw013. Epub 2016Jan 19. No abstract available.PMID: 26786156
Nerves RegulateCardiomyocyte Proliferation and Heart Regeneration.Mahmoud AI, O'Meara CC, Gemberling M, Zhao L, Bryant DM, Zheng R, Gannon JB, Cai L, Choi WY, Egnaczyk GF, Burns CE, Burns CG, MacRae CA, Poss KD, Lee RT.Dev Cell. 2015 Aug 24;34(4):387-99. doi: 10.1016/j.devcel.2015.06.017. Epub 2015 Aug 6.PMID: 26256209
The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA.Cell. 2014 Apr 24;157(3):565-79. doi: 10.1016/j.cell.2014.03.032. Erratum in:Cell. 2014 May 22;157(5):1243.PMID: 24766806
Cardiomyocyte cell cycle: Meis-ing something?Mahmoud AI, Canseco D, Xiao F, Sadek HA.Cell Cycle. 2014;13(7):1057-8. doi: 10.4161/cc.28379. Epub 2014Feb 27. No abstract available.PMID: 24603411
Macrophages are required for neonatal heart regeneration.Aurora AB, Porrello ER, Tan W, Mahmoud AI, Hill JA, Bassel-Duby R, Sadek HA, Olson EN.J Clin Invest. 2014 Mar;124(3):1382-92. doi: 10.1172/JCI72181. Epub 2014 Feb 24.PMID: 24569380
Surgical models for cardiacregeneration in neonatal mice.Mahmoud AI, Porrello ER, Kimura W, Olson EN, Sadek HA.Nat Protoc. 2014 Feb;9(2):305-11. doi: 10.1038/nprot.2014.021. Epub 2014 Jan 16.PMID: 24434799
Hippo pathway effector Yap promotes cardiac regeneration.Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, Porrello ER, Mahmoud AI, Tan W, Shelton JM, Richardson JA, Sadek HA, Bassel-Duby R, Olson EN.Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13839-44. doi: 10.1073/pnas.1313192110.Epub2013 Aug 5.PMID: 23918388
Meis1 regulates postnatal cardiomyocyte cell cycle arrest.Mahmoud AI, Kocabas F, Muralidhar SA, Kimura W, Koura AS,Thet S, Porrello ER, Sadek HA.Nature. 2013 May 9;497(7448):249-253. doi: 10.1038/nature12054. Epub 2013 Apr 17.PMID: 23594737
Harnessing the power of dividing cardiomyocytes.Muralidhar SA, Mahmoud AI, Canseco D, Xiao F, Sadek HA.Glob Cardiol Sci Pract. 2013 Nov 1;2013(3):212-21. doi: 10.5339/gcsp.2013.29. eCollection 2013. Review.PMID: 24689023