Mostafa Zamanian, PhD

Assistant Professor
Pathobiological Sciences
205 Hanson Biomedical Sciences Building
1656 Linden Dr
Madison, WI 53706
(608) 262-0311
Focus Groups: 
Signal Transduction
Research Summary: 
Host-parasite interactions; Vector-borne parasites; Molecular helminthology; Parasite genomics; Drug discovery; Drug resistance; Receptor biology;
Research Detail: 

My laboratory is interested in identifying new drug targets to treat human and animal helminth infections, and in elucidating mechanisms of resistance to existing anti-parasitic drugs. We apply a range of molecular and bioinformatics approaches to guide our work on these fronts. Current projects in the lab include: 1) Discovery and characterization of parasite-specific receptors that are druggable and required for the transmission of mosquito-borne filarial parasites; 2) Identifying new genes and molecular mechanisms involved in nematode parasite drug resistance; and 3) Developing robust new tools for the manipulation and phenotyping of helminths and their vectors. For more detailed information about ongoing projects and opportunities in the lab, please contact us.

Selected Publications: 
Zamanian M, Cook DE, Zdraljevic S, Brady SC, Lee D, Lee J, and Andersen EC. Discovery of unique loci that underlie nematode responses to benzimidazoles. BioRxiv (preprint). (2017)
Lee D, Yang H, Kim J, Brady SC, Zdraljevic S, Zamanian M, Kim H, Paik Y, Krugliak L, Andersen EC, and Lee J. The genetic basis of natural variation in a phoretic behavior. Nature Communications. (2017)
Zamanian M and Andersen EC. Prospects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector‐borne nematode diseases. FEBS Journal. (2016)
Zamanian M, Fraser L, Agbedanu P, Harischandra H, Day TA, Bartholomay L, Kimber MJ. Release of Small RNA-containing exosomes from the human filarial parasite Brugia malayi. PLoS Negl Trop Dis. (2015)
Chan JD, Agbedanu PN, Grab T, Zamanian M, Yang Y, Li F, Dosa PI, Day TA, Marchant JS. Ergot alkaloids (re)generate new leads as antiparasitics. PLoS Negl Trop Dis. (2015)
Chan JD, Agbedanu PN, Zamanian M, Gruba SM, Haynes CL, Day TA, Marchant JS. ‘Death and axes’: unexpected Ca2+ entry phenologs predict new anti-schistosomal agents. PLoS Pathogens. (2014)
Tsai IJ, Zarowiecki M, Holroyd N, Garciarrubio A, Sanchez-Flores A, Brooks KL, Tracey A, Bobes RJ, Fragoso G, Sciutto E, Aslett M, Beasley H, Cai J, Camicia F, Clark R, Cucher M, De Silva N, Day TA, Deplazes P, Estrada K, Fernandez C, Holland PWH, Hou J, Hu S, Huckvale T, Hung SS, Kamenetzky L, Keane JA, Kiss F, Koziol U, Lambert O, Liu K, Luo X, Luo Y, Macchiaroli N, Nichol S, Paps J, Parkinson J, Stantcheva NP, Riddiford N, Rosenzvit M, Salinas G, Wasmuth JD, Zamanian M, Zheng Y, Cai X, Soberón X, Olson PD, Laclette JP, Brehm K, Berriman M. The genomes of four tapeworm species reveal adaptations to parasitism. Nature. (2013)
Zamanian M, Agbedanu PN, Wheeler NW, Kimber MJ, Day TA. Novel RNAi-mediated approach to G protein-coupled receptor deorphanization: proof of principle and characterization of a planarian 5-HT receptor. PLoS One.
Zamanian M, Kimber MJ, McVeigh P, Carlson SA, Maule AG, Day TA. The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism Schmidtea mediterranea. BMC Genomics. (2011)
Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey CR, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM. The Genome of the blood fluke Schistosoma mansoni. Nature. (2009)