Mostafa Zamanian, PhD

Assistant Professor
Pathobiological Sciences
205 Hanson Biomedical Sciences Building
1656 Linden Dr
Madison, WI 53706
(608) 262-0311
Focus Groups: 
Signal Transduction
Research Summary: 
Host-parasite interactions; Vector-borne parasites; Molecular helminthology; Parasite genomics; Drug discovery; Drug resistance; Receptor biology;
Research Detail: 

My laboratory is interested in identifying new drug targets to treat human and animal helminth infections, and in elucidating mechanisms of resistance to existing anti-parasitic drugs. We apply a range of molecular and bioinformatics approaches to guide our work on these fronts. Current projects in the lab include: 1) Discovery and characterization of parasite-specific receptors that are druggable and required for the transmission of mosquito-borne filarial parasites; 2) Identifying new genes and molecular mechanisms involved in nematode parasite drug resistance; and 3) Developing robust new tools for the manipulation and phenotyping of helminths and their vectors. For more detailed information about ongoing projects and opportunities in the lab, please contact us.

Selected Publications: 
Profiling extracellular vesicle release by the filarial nematode Brugia malayi reveals sex-specific differences in cargo and a sensitivity to ivermectin.Harischandra H, Yuan W, Loghry HJ, Zamanian M, Kimber MJ.PLoS NeglTrop Dis. 2018 Apr 16;12(4):e0006438. doi: 10.1371/journal.pntd.0006438. eCollection 2018 Apr.PMID: 29659599
Discovery of genomic intervals that underlie nematode responses to benzimidazoles.Zamanian M, Cook DE, Zdraljevic S, Brady SC, Lee D,Lee J, Andersen EC.PLoS Negl Trop Dis. 2018 Mar 30;12(3):e0006368. doi: 10.1371/journal.pntd.0006368. eCollection 2018 Mar.PMID: 29601575
The genetic basis of natural variation in a phoretic behavior.Lee D, Yang H, Kim J, Brady S, Zdraljevic S, Zamanian M, Kim H, Paik YK, Kruglyak L, Andersen EC, Lee J.Nat Commun. 2017 Aug 17;8(1):273. doi: 10.1038/s41467-017-00386-x.PMID: 28819099
Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal neurotoxicity.Harischandra DS, Ghaisas S, Rokad D, Zamanian M, Jin H, Anantharam V, Kimber M, Kanthasamy A, Kanthasamy AG.Neurotoxicology. 2018 Jan;64:267-277. doi: 10.1016/j.neuro.2017.04.007. Epub 2017 Apr 24.PMID: 28450057
Prospects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector-borne nematode diseases.Zamanian M, Andersen EC.FEBS J. 2016 Sep;283(17):3204-21. doi: 10.1111/febs.13781. Epub 2016 Jul 11. Review.PMID: 27300487
Release of Small RNA-containing Exosome-like Vesicles from the Human Filarial Parasite Brugia malayi.Zamanian M, Fraser LM, Agbedanu PN, Harischandra H, Moorhead AR, DayTA, Bartholomay LC, Kimber MJ.PLoS Negl Trop Dis. 2015 Sep 24;9(9):e0004069. doi: 10.1371/journal.pntd.0004069. eCollection 2015.PMID: 26401956
Ergot Alkaloids (Re)generate New Leads as Antiparasitics.Chan JD, Agbedanu PN, Grab T, Zamanian M, Dosa PI, Day TA, Marchant JS.PLoS Negl Trop Dis. 2015 Sep 14;9(9):e0004063. doi: 10.1371/journal.pntd.0004063. eCollection 2015.PMID: 26367744
Functional analysis of Girardia tigrina transcriptome seeds pipeline foranthelmintic target discovery.Wheeler NJ, Agbedanu PN, Kimber MJ, RibeiroP, Day TA, Zamanian M.Parasit Vectors. 2015 Jan 20;8:34. doi: 10.1186/s13071-014-0622-3.PMID: 25600302
New insights into the FLPergic complements of parasitic nematodes: Informing deorphanisation approaches.McCoy CJ, Atkinson LE, Zamanian M, McVeigh P, Day TA, Kimber MJ,Marks NJ, Maule AG, Mousley A.EuPA Open Proteom. 2014 Apr 19;3:262-272. eCollection 2014 Jun.PMID: 26366373
'Death and axes': unexpected Ca²⁺ entry phenologs predict new anti-schistosomal agents.Chan JD, Agbedanu PN, Zamanian M, Gruba SM, Haynes CL, Day TA, Marchant JS.PLoS Pathog. 2014 Feb 20;10(2):e1003942. doi: 10.1371/journal.ppat.1003942. eCollection 2014 Feb.PMID: 24586156