David Gamm, MD, PhD

Associate Professor
Ophthalmology and Visual Sciences
Address: 
621, T607 Waisman Center
1500 Highland Ave
Madison, WI 53705
Telephone: 
(608) 263-6429
Focus Groups: 
Signal Transduction
Education: 
MD University of Michigan - Ann Arbor
PhD University of Michigan - Ann Arbor
RRF Emmett A. Humble Distinguished Director McPherson Eye Research Institute Sandra Lemke Trout Chair in Eye Research
Research Detail: 

Inherited and acquired degenerative diseases of the retina are a significant cause of incurable vision loss worldwide. Closer to home, I see the impact of these diseases on afflicted individuals and their families in my pediatric ophthalmology practice at the University of Wisconsin. As such, my laboratory at the Waisman Center utilizes stem cell technology to 1) investigate the cellular and molecular events that occur during human retinal differentiation and 2) generate cells for use in human retinal disease modeling and cell-based rescue or replacement strategies. To meet these goals, we utilize a variety of human cell types, including ES and iPS cells, which have the capacity to mimic retinal development and disease, as well as to delineate the genetic "checkpoints" necessary to produce particular retinal cell types. By understanding the behavior of these cell types in vitro and in vivo, we hope to optimize strategies to delay or reverse the effects of blinding disorders such as retinitis pigmentosa and age–related macular degeneration.

Selected Publications: 
Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells.Langer KB, Ohlemacher SK, Phillips MJ, Fligor CM, Jiang P, Gamm DM, Meyer JS.Stem Cell Reports. 2018 Apr 10;10(4):1282-1293. doi: 10.1016/j.stemcr.2018.02.010. Epub 2018 Mar 22.PMID: 29576537
Generation of a rod-specific NRL reporter line in human pluripotent stem cells.Phillips MJ, Capowski EE, Petersen A, Jansen AD,Barlow K, Edwards KL, Gamm DM.Sci Rep. 2018 Feb 5;8(1):2370. doi: 10.1038/s41598-018-20813-3.PMID: 29402929
Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-Derived Retinal Organoids and Fetal Retinae.Lakowski J, Welby E, Budinger D, Di Marco F, Di Foggia V, Bainbridge JWB, WallaceK, Gamm DM, Ali RR, Sowden JC.Stem Cells. 2018 May;36(5):709-722. doi: 10.1002/stem.2775. Epub 2018 Feb 1.PMID: 29327488
Scarless Genome Editing of Human Pluripotent Stem Cells viaTransient Puromycin Selection.Steyer B, Bu Q, Cory E, Jiang K, Duong S, SinhaD, Steltzer S, Gamm D, Chang Q, Saha K.Stem Cell Reports. 2018 Feb 13;10(2):642-654. doi: 10.1016/j.stemcr.2017.12.004. Epub 2018 Jan 4.PMID: 29307579
A Novel Approach to Single Cell RNA-Sequence Analysis Facilitates In Silico Gene Reporting of Human Pluripotent Stem Cell-Derived Retinal Cell Types.Phillips MJ, Jiang P, Howden S, Barney P, Min J, York NW, Chu LF, Capowski EE, Cash A, Jain S, Barlow K, Tabassum T, Stewart R, Pattnaik BR, Thomson JA, Gamm DM.Stem Cells. 2018 Mar;36(3):313-324. doi: 10.1002/stem.2755. Epub 2017 Dec 25.PMID: 29230913
Drusen in patient-derived hiPSC-RPEmodels of macular dystrophies.Galloway CA, Dalvi S, Hung SSC, MacDonald LA, Latchney LR, Wong RCB, Guymer RH, Mackey DA, Williams DS, Chung MM, Gamm DM, PébayA, Hewitt AW, Singh R.Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8214-E8223. doi: 10.1073/pnas.1710430114. Epub 2017 Sep 6.PMID: 28878022
Use of Topical Insulin to Treat Refractory Neurotrophic Corneal Ulcers.Wang AL, Weinlander E, Metcalf BM, Barney NP, Gamm DM, Nehls SM, Struck MC.Cornea. 2017 Nov;36(11):1426-1428. doi: 10.1097/ICO.0000000000001297.PMID: 28742619
β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.Lavine JA, Farnoodian M, Wang S, Darjatmoko SR, Wright LS, Gamm DM, Ip MS, Sorenson CM, Sheibani N.Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):299-308. doi: 10.1167/iovs.16-20204.PMID: 28114591
Bestrophinopathy: An RPE-photoreceptor interface disease.Guziewicz KE, Sinha D, Gómez NM, Zorych K, Dutrow EV, Dhingra A, Mullins RF, Stone EM, Gamm DM, Boesze-Battaglia K, Aguirre GD.Prog Retin Eye Res. 2017 May;58:70-88. doi: 10.1016/j.preteyeres.2017.01.005. Epub 2017 Jan 19. Review.PMID: 28111324
Biallelic Mutations in MITF Cause Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism,and Deafness.George A, Zand DJ, Hufnagel RB, Sharma R, Sergeev YV, Legare JM, Rice GM, Scott Schwoerer JA, Rius M, Tetri L, Gamm DM, Bharti K, Brooks BP.Am J Hum Genet. 2016 Dec 1;99(6):1388-1394.doi: 10.1016/j.ajhg.2016.11.004. Epub 2016 Nov 23.PMID: 27889061