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|William Burlingham, PhD|
Research SummaryAcquired immunologic tolerance; graft acceptance through the study of transplant recipients who have survived even though they have stopped taking immunosuppressive drugs
Dr. Burlingham has developed a highly respected transplant basic research program that focuses on acquired immunologic tolerance. His laboratory hopes to gain insight into graft acceptance by studying transplant recipients who have survived even though they have stopped taking immunosuppressive drugs.
Specifically, his research focuses on the natural exchange of soluble antigens and low numbers of white blood cells that occurs between mother and child during pregnancy and nursing. The lab's working hypothesis is that this exchange, which leads to persistence of bone marrow-derived maternal blood cells within the offspring ("microchimerism") may induce a "natural" form of tolerance. This tolerance, if harnessed, may allow for drug-free acceptance of transplanted grafts.
New directions in the past 3 years include:
Haynes LD, Jankowska-Gan E, Sheka A, Keller MR, Hernandez-Fuentes MP, Lechler RI, Seyfert-Margolis V, Turka LA, Newell KA, Burlingham WJ. Donor-specific indirect pathway analysis reveals a B-cell-independent signature which reflects outcomes in kidney transplant recipients. Am. J. Transplant. 2012 Mar; 12(3):640-8.
Burlingham WJ. Timing is everything in tolerance. Am. J. Transplant. 2012 Mar; 12(3):517-8.
Burlingham WJ., Nelson JL. Microchimerism in cord blood: mother as anticancer drug.. Proc. Natl. Acad. Sci. U.S.A. 2012 Feb 14; 109(7):2190-1.
Jankowska-Gan E, Sheka A, Sollinger HW, Pirsch JD, Hofmann RM, Haynes LD, Armbrust MJ, Mezrich JD, Burlingham WJ. Pretransplant immune regulation predicts allograft correlates with excellent renal transplant function in living-related donor-recipient. Transplantation 2012 Feb 15; 93(3):283-90.
Dutta P, Molitor-Dart M, Bobadilla JL, Roenneburg DA, Yan Z, Torrealba JR, Burlingham WJ. Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice. Blood. 2009;114 (17):3578-87.
Xu Q, Lee J, Keller M, Burlingham WJ. Analysis of indirect pathway CD4+ T cells in a patient with metastable tolerance to a kidney allograft: possible relevance to superior graft survival of HLA class II closely matched renal allografts. Transpl Immunol. 2009 Mar;20(4):203-8.
Burlingham, W.J. A lesson in tolerance--maternal instruction to fetal cells. N Engl J Med. 2009 Mar 26;360(13):1355-7.
Knechtle SJ, Pascual J, Bloom DD, Torrealba JR, Jankowska-Gan E, Burlingham WJ, Kwun J, Colvin RB, Seyfert-Margolis V, Bourcier K, Sollinger HW. Early and Limited Use of Tacrolimus to Avoid Rejection in an Alemtuzumab and Sirolimus Regimen for Kidney Transplantation: Clinical Results and Immune Monitoring. Am J Transplant. 2009 Mar 16. [Epub ahead of print]
Burlingham, W.J. and Goulmy, E.A.J.M. Human CD8+ T Regulatory cells with low avidity TcR specific for minor Histocompatibility antigens. Human Immunol. 2008 ; 69:728-731.
Molitor-Dart ML, Andrassy J, Haynes LD, Burlingham WJ. Tolerance induction or sensitization in mice exposed to noninherited maternal antigens (NIMA). Am J Transplant. 2008 Nov;8(11):2307-15.
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File last updated: August 3, 2012