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Thomas C. Friedrich, PhD
Photo of Thomas C. Friedrich, PhD
Assistant Professor
Pathobiological Sciences
Email: thomasf@primate.wisc.edu
Address:
 555 Science Dr
555 Science Dr
Madison, WI 53711
Phone: 608.265.3381
Education: PhD, University of Wisconsin
Lab Website:
Research Summary
Viral immunity; pathogenesis
Research Detail
In 1918, a global outbreak of "Spanish" influenza killed an estimated 20-100 million people. A strain of influenza virus (H5N1) was discovered in 1997 circulating in chickens in Hong Kong. This H5N1 virus also caused serious, frequently lethal, illness in people. Although H5N1 viruses currently do not efficiently infect humans, the rapid spread of these viruses among wild birds, and the serious illness they cause when they do infect people, have raised concerns that a new pandemic influenza similar to the one that occurred in 1918 could be imminent.
Selected Publications
Reynolds MR, Weiler AM, Weisgrau KL, Piaskowski SM, Furlott JR, Soma T, Gostick E, Musani SK, Price DA, Friedrich TC, Rakasz EG, Wilson NA, McDermott AB, Boyle R, Allison DB, Burton DR, Desrosiers RC, Koff WC, Watkins DI (2008). Macaques vaccinated with live-attenuated SIV control heterologous virus challenge. J Exp Med 205:2537-50
Sacha JB, Reynolds MR, Buechler MB, Chung C, Jonas AK, Wallace LT, Weiler AM, Lee W, Piaskowski SM, Soma T, Friedrich TC, Wilson NA, Watkins DI (2008). Differential antigen presentation kinetics of CD8+ T cell epitopes derived from the same viral protein. J Virol 82:9293-8.
Maness NJ, Yant LJ, Chung C, Loffredo JT, Friedrich TC, Piaskowski SM, Furlott J, May GE, Soma T, Len EJ, Wilson NA, Piontivska H, Hughes AL, Sidney J, Sette A, Watkins DI (2008). Comprehensive immunological evaluation of elite controller and progressor, Mamu-B*17- positive SIV infected rhesus macaques reveals surprisingly few differences. J Virol. 82:5245-54.
Friedrich TC and Watkins DI (2008) Wanted: Correlates of vaccine-induced protection against SIV. Curr Opin HIV AIDS 3:393-8.
Weiler AM, Li Q, Duan L, Kaizu M, Weisgrau K, Friedrich TC, Reynolds MR, Haase AT, Rakasz EG (2008). Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated SIVmac239. J Virol 82:4154-8.
Loffredo JT, Bean AT, Beal DR, Len EJ, May GE, Piaskowski SM, Furlott JR, Reed J, Musani SK, Rakasz EG, Friedrich TC, Wilson NA, Allison DB, Watkins DI (2008). Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control SIVmac239 replication. J Virol 82:1723-38.
Loffredo JT*, Friedrich TC*, Len EJ, Stephany JJ, Rodrigues DS, Spencer SP, Bean AT, Beal DR, Burwitz BJ, Rudersdorf RA, Wallace LT, Piaskowski SM, May GE, Sidney J, Gostick E, Wilson NA, Price DA, Kallas EG, Piontivska H, Hughes AL, Sette A, Watkins DI (2007). CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. PLoS ONE 2:e1152.
Maness NJ, Valentine LE, May GE, Reed J, Piaskowski SM, Soma T, Furlott J, Rakasz EG, Friedrich TC, Hughes AL, Sidney J, Sette A, Wilson NA, Watkins DI. AIDS virus-specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape. J Exp Med 204:2505-12
Sacha JB, Chung C, Reed J, Jonas AK, Bean AT, Spencer SP, Lee W, Vojnov L, Rudersdorf R, Friedrich TC, Wilson NA, Lifson JD, Watkins DI (2007). Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to nef-mediated major histocompatibility complex class I downregulation. J Virol 81:11703-11712.
Friedrich TC, Valentine LE, Yant LJ, Rakasz EG, Piaskowski SM, Furlott JR, Weisgrau KL, Burwitz B, May GE, Len EJ, Soma T, Napoe G, Capuano SV, Wilson NA, Watkins DI (2007). Subdominant CD8+ T cell responses are involved in durable control of AIDS virus replication. J Virol 81:3465-76.
Loffredo JT, Burwitz BJ, Rakasz EG, Spencer SP, Stephany JJ, Giraldo Vela JP, Martin SR, Reed, J, Piaskowski SM, Furlott J, Weisgrau KL, Rodrigues DS, Soma T, Napoe G, Friedrich TC, Wilson NA, Kallas EG, Watkins DI (2007). SIV-specific CD8+ T cell antiviral efficacy is unrelated to epitope specificity and is abrogated by viral escape. J Virol 81:2624-34.
Sacha JB, Chung C, Rakasz EG, Spencer SP, Jonas AK, Bean AT, Lee W, Burwitz B, Stephany J, Loffredo JT, Allison DB, Adnan A, Hoji A, Wilson N, Friedrich TC, Lifson JD, Yang OO, Watkins DI (2007). Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and protein expression. J Immunol 178:2746-54.
Chung C, Lee W, Loffredo JT, Burwitz B, Friedrich TC, Giraldo Vela JP, Napoe G, Rakasz EG, Wilson NA, Allison DB, Watkins DI (2007). Not all cytokine-producing CD8+ T-cells suppress simian immunodeficiency virus replication. J Virol 81:1571-23.
Wiseman RW, Wojechowskyj JA, Greene JM, Blasky AJ, Gopon T, Soma T, Friedrich TC, OConnor SL, OConnor DH (2007). SIVmac239 infection of MHC identical cynomolgus macaques from Mauritius. J Virol 81:349-61.
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