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|M. Suresh, DVM, MVSc, PhD|
Research SummaryMolecular and cellular basis of T cell memory; CD8+ T cell responses in chronic viral infections
Research DetailCD8 T cells play a critical role in defense against viral, intracellular bacterial, and protozoon infections. We are interested in studying the regulation of CD8 T-cell homeostasis during acute and chronic viral infections using the well-characterized mouse model of lymphocytic choriomeningitis virus (LCMV) infection. In an acute LCMV infection, the principal focus of our research is to understand the cellular and molecular basis of the generation of memory T cells. Specifically, we are interested in: 1) studying the role of direct effects of interferon gamma receptor signaling in regulating the survival and differentiation of memory T cells; 2) determining the role of cell cycle regulator p27Kip1 in differentiation of memory cells from effector CD8 T cells; 3) elucidating the importance of FOXO family of transcription factors in regulating memory CD8 T cell homeostasis. In a chronic LCMV infection, we are examining the role of p27Kip1 and E3 ubiquitin ligases in regulating functional responsiveness of virus-specific CD8 T cells.
Sullivan, J. A., E.H. Kim, E. Plisch, and M. Suresh (2012) FOXO3 regulates the CD8 T cell response to a chronic viral infection. J. Virol. (Accepted).
Kim, E.H., J. S. Sullivan E. H. Plisch, M. M. Tejera, A. Jatzek, K. Y. Choi, and M. Suresh (2012) Signal integration by Akt regulates CD8 T cell effector and memory differentiation. J. Immunol. 188(9):4305-14. Epub 2012 Mar 30.
Sullivan, J. A., E. H. Kim, E. Plisch, S. L. Peng, and M. Suresh (2012) FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms. PLOS Pathog. 8(2):e1002533. Epub 2012 Feb 16.
Walsh, K., J. Teijaro, P. Wilker, A. Jatzek, D. Fremgen, S. Das, T. Watanabe, M. Hatta, K. Shinya, M. Suresh, Y. Kawaoka, H. Rosen, and M. Oldstone (2011) Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus. Proc. Natl. Acad. Sci. USA. 108(29):12018-12023.
Nanjappa, S. G., E. H. Kim, and M. Suresh (2011) Immunotherapeutic effects of IL-7 during a chronic viral infection in mice. Blood. 117(19): 5123-5132
Singh, A., A. Jatzek, E. H. Plisch, R. Srinivasan, J. Svaren, and M. Suresh (2010) Regulation of memory CD8 T cell differentiation by p27Kip1. Mol. Cell. Biol. 30(21):5145-59. PMC2953046
Nakayama, Y., E. H. Plisch, J. Sullivan, C. J. Czuprynski, B. R. J. Williams, and M. Suresh (2010) Role of PKR and Type I IFNs in viral control during primary and secondary infection. PLoS Pathog. 6(6):e1000966. PMC2891951
Hatta, Y, K. Hershberger, K. Shinya, S. C. Proll, R. R. Dubielzig, M. Hatta, M. G. Katze, Y. Kawaoka, and M. Suresh (2010) Viral replication rate regulates clinical outcome and CD8 T cell responses during highly pathogenic H5N1 virus infection. PLOS Pathog. 6(10): e1001139. PMC2951384.
Nakayama, Y., C. J. Czuprynski, B. R. J. Williams, and M. Suresh (2009). PKR ad type I IFNs are dispensable for memory T cell expansion but required for viral control during primary and secondary infections. J. Clin. Invest. (In review)
Singh, A., E. H. Plisch, and M. Suresh (2008) p27Kip1 constrains the quantity and quality of CD8 T cell memory by enforcing cell cycle exit of memory precursor effector cells. J. Exp. Med. (Submitted).
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File last updated: August 6, 2012